Faculty and Staff Profiles

Keith R. Martin
Research Asst Professor, College of Health Sciences
Email: krmrtin4@memphis.edu
Office Location:
Office Hours: By appointment
Profile

Keith R. Martin earned his PhD in the field of Nutritional Biochemistry at the University of North Carolina at Greensboro with a focus on dietary antioxidants and reduction of oxidative stress. He went on to do his postdoctoral training in the Laboratory of Nutritional Immunology and Vascular Biology Program at Tufts University in Boston, MA where his work focused on the effects of carotenoids (beta carotene, lutein, etc.) and tocopherols (vitamin E isomers) on vascular function and interaction with immune cells. He then joined the Transgenic Carcinogenesis Unit in the Laboratory of Environmental Carcinogenesis & Mutagenesis (LECM) at the National Institutes of Health (NIH) for postdoctoral training in Research Triangle Park, NC where his research focused on developing genetic models of human cancer to study the effects of antioxidant dose on cancer development. Since transitioning to the University of Memphis, he has focused on the effects of nutraceuticals and dietary supplements on mitigation of chronic disease risk in the Center for Nutraceutical and Dietary Supplement Research (CNDSR) and the College of Health Sciences (CHS).

Education
  • PhD Nutritional Biochemistry - University of North Carolina at Greensboro - 1996
  • Masters Toxicology - North Carolina State University - 2001
  • Bachelors Chemistry and Biology - University of North Carolina at Greensboro - 1987

Work Experience

  • Research Assistant Professor, Center for Nutraceutical & Dietary Supplement Research, College of Health Sciences - University of Memphis - 2017-
  • Consultant, Dietary Supplements & Functional Foods - Scientific Consulting Group, LLC - 2015-2016
  • Assistant Professor, Building Healthy Lifestyles Research Center - Arizona State University - 2007-2013
  • Director of Nutrition Research, Research & Development - Pom Wonderful, Fiji Water, Wonderful Pistachios (Roll, Int.) - 2006-2007
  • Assistant Professor, Nutrition, College of Health & Human Development - Pennsylvania State University - 2001-2006
  • Research Fellow (post-doctoral), Transgenic Carcinogenesis Unit/LECM - National Institutes of Health - 1998-2001
  • Research Fellow (post-doctoral), Nutritional Immunology Laboratory, Vascular Biology Unit - USDA at Tufts University - 1996-1998
Honors/Awards
  • Faculty Processional, Pinning Ceremony, Mentor to Undergraduate Student, Barrett Honors College - Arizona State University - 2017
  • College Faculty Marshal, Mentor to College of Health & Human Development, Valedictorian - Pennsylvania State University - 2005
  • Faculty Mentor, Best competitive manuscript by an undergraduate - Pennsylvania State University - 2005
  • Recipient Block Grant sub-award - Pennsylvania State University - 2004
  • Dannon Institute of Nutrition Leadership Selectee - Danone and Pennsylvania State University - 2003
  • Tewksbury Award for Excellence in Teaching - Tewksbury Foundation - 2002
  • Future Leader Award - International Life Sciences Institute - 2000

Teaching Experience

  • NUTR 4802 Experimental Foods - University of Memphis
  • NUTR 4803 Experimental Foods Laboratories - University of Memphis
  • HSME 7010 Research Methods - University of Memphis
  • ESMS 7020 Publicatons & Proposals in Biomedicine - University of Memphis
  • NUTR 7001 Nutraceuticals & Dietary Supplements - University of Memphis
  • NTR 546 Dietary Assessment - Arizona State University
  • NTR 691 Doctoral Seminar - Arizona State University
  • NTR 535 Nutrigenomics - Arizona State University
  • NTR 442 Experimental Functional Foods - Arizona State University
  • NTR 241 Principles of Nutrition - Arizona State University
  • NUTR 490W Pros & Cons of Dietary Supplementation - Pennsylvania State University
  • IBIOS 602 Supervised Experience in Teaching - Pennsylvania State University
  • NUR 496 Independent Study in Nutrition - Pennsylvania State University
  • NUTR 452 Nutritional Aspects of Health & Disease - Pennsylvania State University
  • NUTR 100 Comtemporary Nutrition - Pennsylvania State University
  • NUTR 100H Public Issues in Nutrition - Pennsylvania State University
  • NUTR 497F Nutraceuticals and Functional Foods - Pennsylvania State University

Student Advising/Mentoring

  • BS - Alexis Salters - 2022
  • BS - Aljowhara Ibrahim Aljeraiwi - 2022
  • BS - Wangkuk Son - 2021
  • BA - Josh Crigger - 2021
  • BS - Suman Sharma - 2021
  • BS - Gabriella Scott - 2021
  • BS - Ashlyn Redmond - 2020
  • BS - Katie Brown - 2019
  • BS - Kemedye Braxton - 2019
  • BS - Allie Turner - 2019
  • BS - Austin Bright - 2019
Service
  • University of Memphis - Guest Editor, OBM Integrative & Complementary Medicine, Nutraceuticals, Dietary Supplements & Cardiometabolic Health - 2021
  • University of Memphis - Editorial Board: Antioxidants - 2021
  • University of Memphis - Editorial Board: Nutraceuticals - 2021
  • University of Memphis - Book Reviewer: Handbook of Nutraceuticals & Natural Products, CRC Press - 2020
  • University of Memphis - Grant Reviewer: Sultan Qaboos University Research Fellowship Program, Oman - 2020
  • University of Memphis - Grant Reviewer: Austrian Science Fund (FWF) Research Programs - 2020
  • University of Memphis - Grant Reviewer The Physiological Society Research Program, London, ENG - 2019
  • University of Memphis - Grant reviewer Graduate Women in Science: National Fellowship Program, USA - 2019
  • University of Memphis - Thesis Committee Member - 2018-current
  • University of Memphis - Search Committee Chair: Assistant Professor - 2019
  • University of Memphis - Search Committee Chair: Research Assistant Professor (position 1) - 2019
  • University of Memphis - Search Committee Chair: Research Assistant Professor (position 2) - 2019
  • University of Memphis - Search Committee: Research Nurse - 2019
  • University of Memphis - Search Committee: Director of Marketing - 2019
  • University of Memphis - Ad hoc Committee, NIH Biomedical Research Facilities Grant - 2019
  • University of Memphis - Ad hoc, SHS Doctoral Program Group - 2019
  • University of Memphis - Editorial Board: Frontiers in Nutrition, Immunology - 2019
  • University of Memphis - Editorial Board: Frontiers in Nutrition, Nutrition and Metabolism - 2019
  • University of Memphis - Editorial Board: Frontiers in Nutrition, Nutrigenomics - 2012-current
  • University of Memphis - Journal Reviewer: Nutrients, Int. J. Molecular Med, Frontiers in Immunology, Frontiers in Nutrition & Metabolism, PLOS One - 2021
Journal Articles
  • Martin, K.R. and Bloomer, R.J. Plasma nitrate and nitrite as biological indicators of health and disease in nutritional studies. In Biomarkers in Disease: Methods, Discoveries, and Applications. V Preedy and VB Patel, Eds. Springer Nature, New York, NY, in press, 2021.
  • Martin, K.R. and Bloomer, R.J. Nitrate and human health: An overview. In: Nitrate Handbook: Environmental, Agricultural, and Health Effects. Ed. Christos Tsadilas, Vol. 1, CRC Press (Taylor & Francis), Boca Raton, FL, Ch. 14, pp. 303-343, 2021.
  • Martin, KR. Dietary nitrates, nitrites, and food safety: Risks versus benefits. Acta Scientific: Nutritional Health, 5(6): 65-76, 2021.
  • Pence, J.C. Martin, K.R. and Bloomer, R.J. Beyond nutrition recommendations: What healthcare professionals should know about dietary supplements to best serve their patients. Health. 13:334-346, 2021.
  • Martin, K.R. Dietary supplementation with L-arginine, single nucleotide polymorphisms of arginase 1 and 2, and plasma L-arginine. Journal of Nutrition, 1-2: nxaa431, doi.org/10.1093/jn/nxaa431, 2021.
  • Pence, JC, Martin, KR, and Bloomer, RJ. Effectively managing the co-ingestion of dietary supplements and prescription drugs. Acta Scientific: Nutritional Health, 5:2, 2021.
  • Martin, K.R., Burrell, L., and Bopp, J. Tart cherry juice consumed daily for 4 weeks does not impair or exacerbate biomarkers of metabolic function in at-risk overweight and obese subjects. Int. J. Functional Nutr. 2:2, 2020.
  • Martin, K.R., Pence, J.C., and Bloomer, R.J. Vitamin D2-enhanced mushrooms as dietary supplements and nutraceuticals: A nutritionally sensible trade-off for the consumer. Clin. J. Nutr. Dietetics. 3(1): 1-7, 2020.
  • Bloomer, R.J., Butawan, M., Pigg, B. and Martin, K.R. Acute ingestion of a novel nitrate-rich dietary supplement significantly increases plasma nitrate/nitrite in physically active men and women. Nutrients. 12(4): 1176-1186, 2020. 
  • Martin, K.R. Contribution of bioavailable silicon in human health, In: Metal Toxicology Handbook, CRC Press/Taylor & Francis, Ed. Debasis Bagchi, University of Houston College of Pharmacy, 1:113-146, 2020.
  • Martin, K. R. and Coles, K. Consumption of 100% tart cherry juice reduces serum urate in overweight and obese adults. Curr. Dev. Nutr. 3(5);nzz011, 2019.
  • Martin, K. R., Burrell, L., and Bopp, J. 100% Tart cherry juice reduces pro-inflammatory biomarkers in overweight and obese subjects. Food Function 9: 5290-5300, 2018.
  • Martin, K. R. Dietary silicon: Is biofortification essential? J. Nutr. Food Sci. Forecast. 1:2: 1006-1007, 2018.
  • K.R. Martin, Silicon. The health benefits of a metalloid, in "Interrelations between Essential Metal Ions and Human Diseases", Vol. 13 of 'Metal Ions in Life Sciences', A. Sigel, H. Sigel, R. K. O. Sigel, Eds.; Springer Science + Business Media B.V., Dordrecht, 2014, Vol. 13, Chapter 4, pp. 451-473, 2014.
  • Tucker, W., Angadi, S. and Martin, K.R. Dietary mushrooms: An excellent source for nutraceuticals capable of reducing risk factors for cardiovascular disease, In: Nutrigenomics: Its Application to the Development of Nutraceuticals (R. Subbiah, Ed.) Nova Science Publishers, New York, NY), Chapter 4, pp. 35-54, 2013.
  • K.R. Martin "Beta-Glucans: Going through GM-CSF to get to dectin,” Comments on “Soluble ß-glucan from Grifola frondosa induces proliferation and dectin-1/Syk signaling in resident macrophages via the GM-CSF autocrine pathway” by Masuda et al.,  J. Leukocyte Biol., 91(4): 521-524, 2012.
  • Martin, K.R. and Wooden, A. Tart cherry juice induces differential dose-dependent effects on apoptosis, but not cellular proliferation, in MCF-7 human breast cancer cells, J. Med. Food, 15(11): 945-954, 2012.
  • Martin, K.R. and Rasmussen, K.K. Comparison of sensory qualities of geographically paired organic and conventional red wines from the Southwestern U.S. with differing total polyphenol concentrations: A randomized pilot study, Food Nutr. Sci., 2: 1150-1159, 2011.
  • Martin, K.R., Beneficial effects of five commonly consumed whole mushrooms and a key bioactive agent, Presented to Greg Seymour, Liaison to the Australian Mushroom Growers Association (AMGA), Ltd. and Horticulture Australia, Ltd. (HAL), Final Published Report for Project number  MU07015, pp. 1-15, 2010.
  • Martin, K.R. Both common and specialty mushrooms inhibit adhesion molecule expression and in vitro binding of monocytes to human aortic endothelial cells in a pro-inflammatory environment, Nutr. J. 9:29, 2010.
  • Martin, K.R. and Brophy, S.K. Commonly consumed and specialty dietary mushrooms reduce cellular proliferation in MCF-7 human breast cancer cells. Exp. Biol. Med., 235: 1306-1314, 2010.
  • Martin, K.R. The bioactive agent ergothioneine, a key component of dietary mushrooms, inhibits monocyte binding to endothelial cells characteristic of early cardiovascular disease. J. Med. Food, 13(6): 1340-1346, 2010.
  • Martin, K.R. and Appel, C.L. Polyphenols as dietary supplements: A double-edged sword, Nutrition and Dietary Supplements, 1:1-12, 2009.
  • Yu, S., Weaver, V., Martin, K.R., and Cantorna, M.T. The effects of whole mushrooms during inflammation. BMC Immunology, 10:12, 2009.
  • Martin, K.R., Rodriguez, G., Krueger, C., Dreher, M., and Reed, J. Development of a novel pomegranate standard and new method for the quantitative measurement of pomegranate polyphenols, J. Sci. Food Agric., 89:157-162, 2009.
  • Martin, K.R. as an invited member of the Systematic Literature Review Group at The Pennsylvania State University (TJ Hartman, PI). Cancers of the oesophagus. In: Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective, WCRF/AICR, Chapter, 7.3, 253-258, 2007.
  • Martin, K.R. as an invited member if the Systematic Literature Review Group at The Pennsylvania State University (TJ Hartman, PI), Cancers of the mouth, pharynx, and larynx. In: Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective, WCRF/AICR, Chapter 7.1, 245-249, 2007.
  • Martin, K.R. as an invited member of the Mechanisms Working Group (MWG) organized by John Milner, Chief, Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute (NCI) and Leader of the MWG, The cancer process. In: Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective, World Cancer Research Fund (WCRF), American Institute for Cancer Research (AICR), Chapter 2, 30-46, 2007. 
  • Invited book review. Pomegranates: Ancient Roots to Modern Medicine. Medicinal and Aromatic Plants-Industrial Profiles (Eds. Navindra P. Seeram, Risa N. Schulman, and David Heber; CRC, Taylor & Francis). Review appears in the J. Amer. Botanical Council, 75: 67-68, 2007.
  • Zhao, G., Etherton, T.D., Martin, K.R., Gillies, P.J., West, S.G. and Kris-Etherton, P.M. Dietary alpha linoleic acid inhibits proinflammatory cytokine production by peripheral blood mononuclear cells in hypercholesterolemic subjects. Am. J. Clin. Nutr., 85(2), 385-391, 2007.
  • Martin, K.R. Using nutrigenomics to evaluate apoptosis as a preemptive target in cancer prevention. Curr. Cancer Drug Targets, 7(5), 438-446, 2007.
  • Martin, K.R. The chemistry of silica and potential health benefits, J. Nutr. Health Aging, 11(2), 94-98, 2007.
  • Martin, K.R. Targeting apoptosis with dietary bioactive agents. Exp. Biol. Med. 231(2), 117-129, 2006.
  • Young, L.F. and Martin, K.R. Time-dependent resveratrol-mediated mRNA and protein expression associated with cell cycle in WR-21 cells containing mutated human c-Ha-ras. Mol. Nutr. Food Sci. 50(1), 70-77, 2006.
  • Young, L.F., Hantz, H.L and Martin, K.R. Resveratrol modulates gene expression associated with apoptosis, proliferation and cell cycle in cells with mutated human c-Ha-ras, but does not alter c-Ha-ras mRNA or protein expression. J. Nutr. Biochem. 16(11), 663-674, 2006.
  • Zhao, G., Etherton, T.D., Martin, K.R., Vandel Heuvel, J.P., Gillies, P.J., West, S.G., Kris-Etherton, P.M., and Etherton, T. Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells. Biochem. Biophys. Res. Comm. 336: 909-917, 2005.
  • Hantz, J.L., Young, L.F. and Martin, K.R. Physiologically attainable concentrations of lycopene do not alter cellular proliferation, but induce apoptosis in LNCaP human prostate cancer cells. Exp. Biol. Med. 230(3), 171-179, 2005.
  • Zhao, G., Etherton, T.D., Martin, K.R., Gillies, P.G. and Kris-Etherton, P.M. Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women. J. Nutr. 134: 2991-2997, 2004.
  • Martin, K.R., Jokinen, M.P., Honeycutt, H.P., Quinn, A., Kari, F.W., Barrett, J.C., and French, J.E. Tumor profile of novel p53 heterozygous Tg.AC (v-ha-ras) bitransgenic mice treated with benzo(a)pyrene and fed dietary N-acetyl-L-cysteine (NAC). Toxicol. Sci.  81(2): 293-301, 2004.
  • Martin, K.R., Jokinen, M.P., Honeycutt, H.P., Quinn, A., Kari, F.W., Barrett, J.C., and French, J.E. Tumor spectrum in the p53 heterozygous zeta globin-promoted Tg.AC (v-Ha-ras) bitransgenic mouse model. Toxicol. Pathol. 32(4): 418-425, 2004.
  • Martin, K.R. and Barrett, J.C. The Role of ROS in Health and Disease, Biological Effects of Low Level Exposures (BELLE), 10(2): 10-13, 2002.
  • Agostinucci, K., Manfredi, T.G., Cosmas, A., Martin, K.R., Han, S.N., Wu, D.,Sastre, J.,  Meydani, S.N. and Meydani, M. Vitamin E and age alter mouse liver mitochondrial morphometry. Journal Anti-Aging Medicine 5(2): 173-178, 2002.
  • Martin, K.R., Saulnier, M., Kari, F.W., Barrett, J.C. and French, J.E. Timing of supplementation with the antioxidant N-acetyl-L-cysteine reduces tumor multiplicity in novel, cancer-prone p53 haploinsufficient Tg.AC (v-Ha-ras) transgenic mice, but has no impact on malignant progression. Nutrition & Cancer, 43(1): 59-66, 2002.
  • Martin, K.R. and Barrett, J.C. Reactive oxygen species as double-edged swords in cellular processes: low-dose cell signaling versus high-dose toxicity. Human Exp. Toxicol., 21(2): 71-76, 2002.
  • Meydani, M. and Martin, K.R. Intestinal absorption of fat-soluble vitamins. In: Intestinal Lipid Metabolism. (Mansbach C, Tso P, and Kuksis A, eds.) Plenum Publishing Corp., New York, N.Y., Chapter 20, pp. 367-382, 2001
  • Martin, K.R., Trempus, C., Saulnier, M.J., Barrett, J.C., Kari, F.W., and French, J.E. Dietary N-acetyl-L-cysteine modulates benzo(a)pyrene-induced skin tumors in cancer-prone p53 haploinsufficient Tg.AC (v-Ha-ras) mice. Carcinogenesis, 22(9); 1373-1378, 2001.
  • Martin, K.R., Kari, F.W., Barrett, J.C., and French, J.E.  N-acetyl-L-cysteine concurrently increases mitogenesis and suppresses apoptosis in mitogen-stimulated B-lymphocytes from p53 haploinsufficient Tg.AC (v-Ha-ras) mice. In Vitro & Mol. Toxicol. 13: 234-247, 2000.
  • Martin, K.R., Wu, D., and Meydani, M. The effect of carotenoids on the expression of cell surface adhesion molecules and binding of monocytes to human aortic endothelial cells. Atherosclerosis, 150: 265-274, 2000.
  • Wu, D., Meydani, M., Beharka, A.A., Serafini, M., Martin, K.R., and Meydani, S.N. In vitro supplementation with different tocopherol homologues can affect the function of immune cells in old mice. Free Rad. Biol. Med. 28: 643-651, 2000.
  • Wu, D., Koga, T., Martin, K.R., and Meydani, M. Effect of vitamin E on human aortic endothelial cell production of chemokines and adhesion to monocytes. Atherosclerosis, 147: 297-307, 1999.
  • Meydani, M., Fielding, R.F., and Martin, K.R. Vitamin E and its Effect on Skeletal Muscle. In: Oxidative Stress in Skeletal Muscle, Series: Molecular and Cell Biology Updates, (Reznick AZ, Packer L, Sen CK, Holloszy, JO, and Jackson MJ, eds.) Birkhauser Verlag AG, Basel, Switzerland, Chapter 9, pp. 141-156, 1998.
  • Lipman, R.D., Bronson, R.T., Wu, D., Smith, D.E., Prior, R., Cao, G., Han, S. Martin, K.R., Meydani, S.N. and Meydani, M. Disease incidence and longevity are unaltered by dietary supplementation initiated during middle age in C57BL/6 mice, Mech. Ageing Dev., 103: 269-284, 1998.
  • Martin, K.R., Failla, M.L. and Smith, J.C., Jr. Differential Susceptibility of Caco-2 and HepG2 human cell lines to oxidative stress, J. Elisha Mitchell Scientific Society, 96(4): 149-162, 1998.
  • Meydani, M., Lipman, R.D., Han, S.N., Wu, D., Beharka, A., Martin, K.R., Bronson, R., Cao, G., Smith, D. and Meydani, S.N. The effect of long-term dietary supplementation with antioxidants.  Annals of N.Y. Academy Sciences 854: 352-360, 1998.
  • Meydani, M. and Martin, K.R. Free Radicals and Aging. Free Radicals in Clinical Medicine. 12:3-8, 1997.
  • Martin, K.R., Loo, G. and Failla, M.L. Human lipoproteins as a vehicle for delivery of beta-carotene and a-tocopherol to HepG2 cells. Proc. Soc. Exp. Biol. Med. 217:1-7, 1997.
  • Martin, K.R., Failla, M.L. and Smith, J.C., Jr. Beta-Carotene and lutein protect HepG2 cells against pro-oxidant induced stress. J. Nutr. 126: 2098-2106, 1996.
Presentations
  • Building Healthy Lifestyles Conference: Nutrition for Optimal Health and Performance, "Functional Foods for Optimal Health: Bitter Mushrooms, Sour Cherries, Sweet Success," Arizona State University, Tempe, AZ, 2012. 
  • Building Healthy Lifestyles Conference: From Research to Practice, “Functional Foods as Immune System Modulators: Dietary Mushrooms, Tart Cherries, and More,” Arizona State University, Mesa, AZ, 2010.
  • Keynote Speaker, Healthier Wines From Organic Vines, State meeting of the Arizona Dietetics Association (AZDA), Scottsdale, AZ, 2009.
  • The Super Power of Polyphenol Antioxidants in Functional Foods: Chocolate, pomegranates, and more, The Hershey Company, Hershey, PA, 2008.
  • DSHEA and Dietetics: Reporting Adverse Effects From the Clinical Setting, North Regional Arizona Dietetics Association (AZDA), Kingman, AZ, 2008.
  • North Regional Arizona Dietetics Association (AZDA), Having the Right Equipment for the Game; The Importance of Phytochemicals, Prescott Valley, AZ, 2008.