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Faculty and Staff Profiles |
DANIEL L BAKER |
Professor, Chemistry |
Email: dlbaker@memphis.edu |
Office Location: |
Office Hours: By Appointment |
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Education
- BS Chemistry - Central Michigan University - 1992
- PhD Pharmacology and Toxicology - University of Arizona - 1998
Work Experience
- Postdoctoral Trainee, Department of Physiology - University of Tennessee Health Science Center - May 1998- June 2001
- Postdoctoral Fellow (American Heart Association), Department of Neurology - University of Tennessee Health Science Center - July 2001- June 2003
- Instructor, Department of Physiology - University of Tennessee Health Science Center - May 2003
- Associate Member,   - University of Tennessee Cancer Institute - December 2003- June 2006
- Member, Genomics and Bioinformatics Center of Excellence - University of Tennessee Health Science Center - June 2003- June 2006
- Member, Vascular Biology Center of Excellence - University of Tennessee Health Science Center - June 2003- June 2006
- Assistant Professor, Department of Medicine - University of Tennessee Health Science Center - June 2003- June 2006
- Assistant Professor, Department of Chemistry - University of Memphis - August 2006- August 2012
- Associate Professor, Department of Chemistry - University of Memphis - September 2012- August 2022
- Adjunct Associate Professor, Department of Physiology - University of Tennessee Health Science Center - June 2015- May 2018
- Professor, Department of Chemistry - University of Memphis - September 2022 -
Honors/Awards
- Dunavant Travel Award - College of Arts and Sciences, Univeristy of Memphis - Summer 2007
- Professional Development Assignment - College of Arts and Sciences, University of Memphis - Summer/Fall 2015
- Faculty Research Grant - College of Arts and Sciences, University of Memphis - Summer 2015
- RIF Grant - University of Memphis - 2017-18
Teaching Experience
- CHEM 1010 "Chemistry of Materials" - University of Memphis
- CHEM 1020 "Chemistry of Life" - University of Memphis
- CHEM 1021 "Chemistry of Life" Lab - University of Memphis
- CHEM 3501 "Foundations of Bioorganic Chemistry Lab" - University of Memphis
- CHEM 3511 "Foundations of Bioorganic Chemistry" - University of Memphis
- CHEM 4315/ 6315 "Organic Medicinal Chemistry" - University of Memphis
- CHEM 4580/ 6580 "Chemical Biology" - University of Memphis
- CHEM 7505/ 8505 "Protein Mass Spectrometry" - University of Memphis
Student Advising/Mentoring
- MS - Ben Clayton (Co-mentored with Abby Parrill) - 2007
- MS - Jeff North (Co-mentored with Abby Parrill) - 2007
- MS - Angela Howard (Co-mentored with Abby Parrill) - 2007
- PhD - Adrienne Hoeglund (Co-mentored with Abby Parrill) - 2009
- MS - Irene Wanjala (Co-mentored with Abby Parrill) - 2010
- PhD - Irene Wanjala (Co-mentored with Abby Parrill) - 2010
- PhD - Jeff North (Co-mentored with Abby Parrill) - 2010
- PhD - Angela Howard (Co-mentored with Abby Parrill) - 2011
- PhD - Ben Clayton (Co-mentored with Abby Parrill) - 2011
- MS - Jacob McMillan (Co-mentored with Abby Parrill) - 2013
- BS - Whitney Scott - 2013
- BS (Honors) - Melanie Sparks - 2013
- MS - Lauren Ragle (Co-mentored with Abby Parrill) - 2013
- PhD - Jacob McMillan (Co-mentored with Abby Parrill) - 2014
- MS - Krista Bearden - 2014
- MS - Samantha Gacasan (Co-mentored with Abby Parrill) - 2015
- PhD - Lauren Ragle (Co-mentored with Abby Parrill) - 2016
- MS - Babtunde Raji - 2016
- PhD - Samantha Gacasan (Co-mentored with Abby Parrill) - 2017
- MS - Lee Wink (Co-mentored with Abby Parrill) - 2017
- MS - Keri Hannie - 2017
- PhD - Babtunde Raji - 2018
- MS - Jay Yarbro (Co-mentored with Ramin Homayouni) - 2018
- PhD - Lee Wink (Co-mentored with Abby Parrill) - 2018
- BS (Honors) - Chandler Sears (Co-mentored with Abby Parrill) - 2019
- PhD - Keri Hannie - 2020
- MS - Paige Castleman (Co-mentored with Abby Parrill) - 2019
- MS - Christy Dyer (Co-mentored with Abby Parrill) - 2020
- MS - Brian Hoffman - 2020
- MS - Greg Szwabowski (Co-mentored with Abby Parrill) - 2020
- PhD - Paige Castleman (Co-mentored with Abby Parrill) - 2021
- MS - E. Rachel Wiley - 2021
- MS - Makenzie Griffing (Co-mentored with Abby Parrill) - 2021
- Thesis MS - Brittany Thomas (Co-mentored with Abby Parrill) - 2021
- PhD - Greg Szwabowski (Co-mentored with Abby Parrill) - 2022 (anticipated)
- MS - Hayden Criswell - 2022
- PhD - Christy Dyer (Co-mentored with Abby Parrill) - 2023 (anticipated)
- PhD - Brian Hoffman - 2023 (anticipated)
- PhD - E. Rachel Wiley - 2023 (anticipated)
Support
- Scientist Development Grant "Lysophosphatidic Acid in Human Lipoproteins: Mechanism of Formation and Modulation of Atherogenic Potential" (PI) - American Heart Association - $263,000 - July 2005 - June 2009
- "MRI: Acquisition of a Liquid Chromatograph-Mass Spectrometer (LC-MS) for Research and Education” - National Science Foundation - $365,600 - August 2006 - July 2009
- “MPO and NO Signaling in Neointima” (subcontract) - National Institutes of Health - $23,287 - August 2006 - July 2011
- "MRI: Acquisition of a Spectropolarimeter for Research and Education" (Senior Personnel) - National Science Foundation - $137,000 - August 2007 - July 2010
- "Identification of ATX Inhibitors as Potential Cancer Chemotheraputic Leads" (Co-PI) - Elsa Pardee Foundation - $100,770 - January 2008 - December 2008
- “REU Site – Collaborative Chemistry Research At the University of Memphis” (Senior Personnel) - National Science Foundation - $220,229 - Februrary 2009 - March 2011
- "REU Site: University of Memphis Interdisciplinary Research in Chemistry" (Senior Personnel) - National Science Foundation - $270,000 - September 2012 - August 2015
- "MRI: Acquisition of a 400 MHz NMR Spectrometer" (Co-I) - National Science Foundation - $339,585 - August 2015 - July 2018
- "Corrdinated Regulation of MAP3K4 of Epigenetic Modifiers" (Co-I) - National Institutes of Health - $1,730,421 - September 2015 - August 2020
- "GPR88 Ligand Discovery" (Co-PI) - National Institutes of Health - $408,733 - May 2016 - April 2019
- Contract - RXBio, INC - $10,364 - January 2016 - May 2016
- Contract - RXBio, INC - $4,305 - July 2016 - August 2016
- Contract (Co-PI) - Maplight Therapeutics - $16,582 - September 2020 - December 2020
- "Acetylated Electrospun Biopolymer Membranes for Burn Wound Coverage, Infection Prevention, and Pain Relief" (Co-I) - Department of Defense, Military Burn Research program - $499,315 - January 2020 - December 2021
- “Development of acylated nanofibrous chitosan membranes for pre-hospital traumatic wound coverage, inhibition of infection, and pain mitigation” (Co-I) - Department of Defense, Peer Reviewed Medical Research Program - $286,156 - November 2020 - October 2022
- Startup Funds - University of Memphis - $150,000 - August 2006 - July 2008
- Research Grant - FedEx Institute of Technology - $60,000 - November 2009 - October 2010
- Research Grant - FedEx Institute of Technology - Memphis Research Foundation - $100,000 - January 2011 - December 2011
- Research Grant - FedEx Institute of Technology - $18,750 - January 2013 - June 2014
- Faculty Research grant - University of Memphis, College of Arts and Sciences - $6,000 - January 2015 - December 2015
- Discovery & Development Grant - FedEx Institute of Technology - $19,900 - March 2017 - August 2018
- Development & Discovery Grant - FedEx Institute of Technology - $20,000 - July 2018 - June 2019
- Gap Funding - University of Memphis (Div of Research & Innovation) - $20,000 - February 2020 - June 2020
- Faculty Research Grant - University of Memphis, College of Arts and Sciences - $10,000 - July 1, 2023 - June 30, 2024
Service
- University of Memphis - Graduate Studies Committee (Dept. of Chemistry) - 2006 - 2015, 2019 - current
- University of Memphis - University Radiation Safety Committee - 2006 - 2022
- University of Memphis - Undergraduate Research Conference Coordinator - 2008 - 2014
- University of Memphis - Tenure & Promotion Committee (College of Arts & Sciences) - 2012 - 2014, 2018-2019
- University of Memphis - Chair - Tenure & Promotion Committee (Dept. of Chemistry) - 2014, 2018 - 2019
- University of Memphis - Chair - Tenure & Promotion Committee (College of Arts & Sciences) - 2014
- University of Memphis - Graduate Coordinator (Dept. of Chemistry) - 2014, 2019 - current
- University of Memphis - Undergraduate Studies Committee - 2016 - 2019
- University of Memphis - NSF GRFP Fellowship Coordinator - 2018 - 2020
Journal Articles
- Baker, D.L., Krol, E.S., Jacobson, N., and Liebler, D.C. (1999) Reactions of beta-carotene with cigarette smoke oxidants: Identification of carotenoid oxidation products and evaluation of the prooxidant/antioxidant effect. Chem. Res. Toxicol. 12:535-543.
- Bautista, D.L., Baker, D.L., Wang, D., Fischer, D.J., van Brocklyn, J., Spiegel, S., Tigyi, G., and Parrill, A.L. (2000) Dynamic modeling of EDG1 receptor structural changes induced by site-directed mutations. Journal of Molecular Structure - Theochem. 529:219-224.
- Parrill, A.L., Wang, D., Bautista, D.L., Van Brocklyn, J.R., Lorincz, Z., Fischer, D.J., Baker, D.L., Liliom, K., Spiegel S., and Tigyi, G. (2000) Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate, J. Biol. Chem. 275:39379-39384.
- Liliom, K., Sun, G., Bunemann, M., Virag, T., Nusser, Baker, D.L., Wang, D., Fabian, M.J.N., Brandts, B., Bender, K., Eickel, A., Malik, K.U., Miller, D.D., Desiderio, D.M., Tigyi, G., and Pott, L. (2001) Sphingosylphosphorylcholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors. Biochem. J. 355:189-197.
- Baker, D.L., Desiderio, D.M., Miller, D.D., and Tigyi, G.J. (2001) Direct quantitative analysis of lysophosphatidic acid molecular species by stable isotope dilution electrospray ionization liquid chromatography mass spectrometry. Anal. Biochem. 292:287-295.
- Fischer, D.J., Nusser, N., Virag, T., Yokoyama, K., Wang, D., Baker, D.L., Bautista, D., Parrill, A.L., and Tigyi, G.J. (2001) Short-chain phosphatidates are subtype-selective antagonists of lysophosphatidic acid receptors. Mol. Pharm. 60:776-784.
- Sardar, V.M., Bautista, D.L., Fischer, D.J., Yokoyama, K., Nusser, N., Virag, T., Wang, D., Baker, D.L., Tigyi, G., and Parrill, A.L. (2001) Molecular basis for lysophosphatidic acid receptor antagonist selectivity. Biochim. Biophys. Acta 1582:310-318.
- Yokoyama, K., Baker, D.L., Virag, T., Liliom, K., Byun, H., Tigyi, G., and Bittman, R. (2001) Stereochemical properties of lysophosphatidic acid signaling and metabolism. Biochim. Biophys. Acta 1582: 296-309.
- Sano, T., Baker, D.L., Wada, A., Yatomi, Y., Kobayashi, T., Igarashi, Y., and Tigyi, G.J. (2002) Multiple mechanisms linked to platelet activation generate lysophosphatidic acid and sphingosine-1-phosphate in blood. J. Biol. Chem. 277:21197-21206.
- Baker, D.L., Morrison, P., Miller, B., Riely, C.A., Tolley, B., Bonfrer, J.M.G., Westermann, A.M., Moolenaar, W.H., and Tigyi, G.J. (2002) Lack of a Diagnostic Correlation Between Plasma Lysophosphatidic Acid Concentration and Ovarian Cancer. JAMA 287: 3081-3082.
- Rother, E., Brandl, R., Baker, D.L., Tigyi, G., and Siess, W. (2003) Inhibition of platelet activation induced by lysophosphatidic acid, mildly oxidized LDL and plaque lipid core by subtype-selective antagonists of lysophosphatidic acid receptors. Circulation 108: 741-747.
- Yue, J., Yokoyama, K., Balazs, L., Baker, D.L., Pilquil, C., Brindley, D.N., and Tigyi, G. (2004) Transgenic overexpression of LPP1 results in multiple phenotypic abnormalities that are independent of LPA signalling. Cell. Signalling 16:385-399.
- Zhang, C., Baker, D.L., Yasuda, S., Makarova, N., Johnson, L.R., Balazs, L., McIntyre, T.M., Xu, Y., Prestwich, G.D., Byun, H-S., Bittman, R., and Tigyi, G. (2004) Lysophosphatidic acid induces neointima formation through PPARg activation. J. Exp. Med. 199: 763-774.
- Fujiwara, Y., Sardar, V., Tokumura, A., Baker, D.L., Murakami-Murofudhi, K., Parrill, A., and Tigyi, G. (2005) Identification of residues responsible for ligand recognition and regioisomeric selectivity of LPA receptors expressed in mammalian cells. J Biol. Chem. 280: 35038-35050.
- Liebler, D.C., and Baker, D.L. (1998) Reactions of b-carotene with cigarette smoke: is b-carotene a prooxidant or an antioxidant? In Biological Oxidants and Antioxidants: Molecular Mechanisms and Health Effects, (Packer, L. ed), pp. 65-71, AOCS Press, Champaign, IL
- Tigyi, G., Fischer, D.J., Baker, D., Wang, D., Yue, J., Nusser, N., Virag, T., Zsiros, V., Liliom, K., Miller, D. and Parrill, A. (2000) Pharmacological characterization of phospholipid growth-factor receptors. In Lysophospholipids and Eicosanoids in Biology and Pathophysiology (Goetzl, E.J. and Lynch, K.R., eds) Vol. 905, pp. 34-53, New York Academy of Sciences, New York
- Parrill, A. L., Baker, D.L., Wang, D., Fischer, D.J., Bautista, D.L., Van Brocklyn, J., Spiegel, S. and Tigyi, G., Structural features of EDG1 receptor-ligand complexes revealed by computational modeling and mutagenesis. In Lysophospholipids and Eicosanoids in Biology and Pathophysiology, (Goetzl, E.J. and Lynch, K.R., eds) Vol. 905, pp. 330-339 New York Academy of Sciences, New York
- Baker, D.L., Umstodt, E.S., Desiderio, D.M., and Tigyi, G.J., Quantitative analysis of lysophosphatidic acid in human blood fractions. In Lysophospholipids and Eicosanoids in Biology and Pathophysiology, (Goetzl, E.J. and Lynch, K.R., eds) Vol. 905, pp. 267-269 New York Academy of Sciences, New York
Gududuru, V., Zeng, K., Tsukahara, R., Makarova, N., Fujiwara, Y., Pigg, K.R., Baker, D.L.,
Tigyi, G., and Miller, D.D. (2006) Identification of Darmstoff
analogs as selective agonists and antagonists of lysophosphatidic acid
receptors. Bioorg. Med. Chem. Lett. 16: 451-456. - Durgam, G.G., Tsukahara, R., Makarova, N., Fujiwara, Y., Pigg, K.R., Baker, D.L., Sardar, V., Parrill, A.L., Tigyi, G., and Miller, D.D. (2006) Synthesis and pharmacological evaluation of second-generation phosphatidic acid derivatives as lysophosphatidic acid receptor ligands. Bioorg. Med. Chem. Lett. 16: 633-640.
- Li, Z., Baker, D.L., Tigyi, G., and Bittman, R. (2006) Synthesis of Photoactivatable Analogues of Lysophosphatidic Acid and Covalent Labeling of Plasma Proteins. J Org. Chem. 71: 629-635.
- Tsukahara, T., Tsukahara, R., Yasuda, S., Makarova, N., Valentine, W.J., Yuan, H., Baker, D.L., Li, Z., Bittman,R., Parrill, A.L., and Tigyi, G. (2006) Ether Analogs of Lysophosphatidic Acid are Endogenous High-Affinity Partial Agonists of PPARg1. J Biol. Chem. 281: 3398-3407.
- Baker, D.L., Fujiwara, Y., Pigg, K.R., Tsukahara, R., Kobayashi, S., Uchiyama, A., Murakami-Murofushi, K., Koh, E., Bandle, R.W., Byun, H., Bittman, R., Murphy, M., Fiedler A., Mills, G.B., and Tigyi, G. (2006) Carba Analogs of Cyclic Phosphatidic Acid Are Selective Inhibitors of Autotaxin and Cancer Invasion. J Biol. Chem. 281: 22786-22793.
- Parrill, A.L., Echols, U., Nguyen, T., Pham, T.T., Hoeglund, A., and Baker, D.L. (2008) Virtual screening approaches for the identification of non-lipid autotaxin inhibitors. Bioorg. Med. Chem. 16: 1784-1795.
- Parrill, A.L. and Baker, D.L. (2008) Autotaxin Inhibition: Challenges and Progress Toward Novel Anti-Cancer Agents. Anti-Cancer Agents in Med. Chem. 8: 917-923.
- Parrill, A. L. and Baker, D. L., Provisional patent application 61/002,687 “Method for the Identification of Compounds Used in the Treatment of Certain Tumors Using Autotaxin Inhibitors as Chemotherapeutic Compounds and the Method of Treating Tumors Using Those Compounds”, provisional filing date 11/13/2007, patent filing date 11/13/2008.
- Parrill, A.L., Baker, D.L., and Montedonico, L. Provisional patent application 61/102,723 “Mechanism-Based Inactivators of Autotaxin”, provisional filing date 10/3/2008.
- North, E.J., Osborne, D.A., Bridson, P.K., Baker, D.L., and Parrill, A.L. (2009) Autotaxin structure-activity relationships revealed through lysophosphatidylcholine analogs. Bioorg. Med. Chem. 17: 3433-3442.
- Parrill, A., Baker, D.L., and North, E.J., Provisional patent application 61/221,969, "Autotaxin Inhibitor Pharmacophore Method", provisional filing date 6/30/2009.
- Parrill, A., Baker, D.L., North E.J., Provisional patent application 61/222,022, "Novel Diverse Lead Compound Autotaxin Inhibitors", provisional filing date 6/30/2009.
- Hoeglund, A.B., Howard, A.L., Wanjala, I.W., Pham, T.T., Parrill, A.L., and Baker, D.L., (2010) Characterization of non-lipid autotaxin inhibitors. Bioorg. Med. Chem. 18: 769-776.
- Hoeglund, A.B., Bostic, H.E., Howard, A.L., Wanjala, I.W., Best, M.D., Baker, D.L., and Parrill, A.L., (2010) Optimization of a pipemidic acid autotaxin inhibitor. J. Med. Chem. 53: 1056-1066.
- North, E.J., Howard, A.L., Wanjala, I.W., Pham, T.T., Baker, D.L., and Parrill, A.L., (2010) Pharmacophore Development and application toward the identification of novel, small-molecule autotaxin inhibitors. J. Med. Chem. 53: 3095-3105.
- Valentine, W.J., Kiss, G.N., E, S., Gotoh, M., Murakami-Murofushi, K., Pham, T.C., Baker, D.L., Parrill, A.L., Lu, X., Bittman, R., Pyne, N.J., and Tigyi, G., (2010) (S)-FTY720-Vinylphosphonate, an Analogue of the Immunosuppressive agaent FTY720, is a Pan-antagonist of Sphingosine 1-Phosphate GPCR Signalling and Inhibits Autotaxin Activity. Cell Signal. 22: 1543-1553.
- Tsukahara, T., Tsukahara, R., Fujiwara, Y., Cheng, Y., Guo, H., Bolen, A., Zhang, C., Balazs, L., Re, F., Frohman, M.A., Baker, D.L., Parrill A.L., Uchiyama, A., Kobayashi, T., Murakami-Murofushi, K., and Tigyi, G., (2010) Phospholipase D2-Dependent Inhibition of the Nuclear Hormone Receptor PPARγ by cyclic Phosphatidic Acid. Molecular Cell 39: 421-432.
- Parrill, A.L. and Baker
D.L., (2010) Autotaxin
Inhibitors: A Perspective on Initial
Medicinal Chemistry Efforts. Expert. Opin. Ther. Pat. 20: 1619-1625.
- Gupte, R., Siddam, A., Li, W., Fujiwara, Y.,
Panupinthu, N., Pahm, T.C., Baker,
D.L., Parrill, A.L., Gotoh, M.m Murakami-Murofushi, K., Kobayashi, S.,
Mills, G.B., Tigyi, G, and Miller, D.D., (2010) Synthesis and Pharmacological
Evaluation of the Stereoisomers of 3-Carba Cyclic-Phosphatidic Acid. Bioorg.
Med. Chem. Lett. 20: 7525-7528.
- Gupte,
R., Patil, R., Liu, J., Wang, Y., Lee, S.C., Fujiwara, Y., Fells, J., Bolen,
A.L., Emmons-Thompson, K., Yates, C.R., Siddam, A., Panupinthu, N., Pham, T.C.,
Baker, D.L., Parrill, A.L.,
Mills, G.B., Tigyi, G., and Miller, D.D., (2011) Benzyl and
Naphthalene-Methyl Phosphonic Acid Inhibitors of Autotaxin with Anti-invasive
and Anti-metastatic Actions, Chem.
Med. Chem. 6: 922-935.
- Bolen,
A.L., Naren, A.P., Yarlagadda, S., Beranova-Giorgianni, S., Chen, L., Norman,
D.D., Baker, D.L., Rowland, M.M., Best, M.D., Sano, T., Tsukahara, T., Liliom,
K., Igarashi, Y. and Tigyi, G., (2011) The Phospholipase A1 Activity
of Lysophospholipase A-1 Links Platelet Activation to LPA Production During
Blood Clotting. J. Lipid Res. 52: 958-970.
- Parrill
A.L., Wanjala I.W., Pham T.C., and Baker
D.L., (2011) Computational identification and experimental
characterization of substrate binding determinants of nucleotide
pyrophosphatase/phosphodiesterase 7. BMC Biochem. 12:65.
- Mize
C.D., Abbott A.M., Gacasan S.B., Parrill A.L., Baker D.L., (2011) Ligand-based autotaxin pharmacophore models
reflect structure-based docking results. J Mol Graph Model.
31:76-86.
- Singh
W.M., Baine T., Kudo S., Tian S., Ma X.A., Zhou H., Deyonker N.J., Pham T.C.,
Bollinger J.C., Baker D.L.,
Yan B., Webster C.E., Zhao X., (2012) Electrocatalytic and Photocatalytic
Hydrogen Production in Aqueous Solution by a Molecular Cobalt Complex. Angew. Chem. Int. Ed. Engl. 51(24):5941-4.
- Ren,
F., Bhana, S., Norman, D., Johnson, J., Xu, L., Baker, D., Parrill, A., and Huang,
X., (2013) Gold Nanorods Carrying Paclitaxel for Photothermal - Chemotherapy of Cancer,
Bioconjugate Chem., 24(3),
376-386.
- Baker
D.L., Pham T.C., and Sparks M.A., (2013) Structure and Catalytic Function of Sphingosine
Kinases: Analysis by Site-Directed Mutagenesis and Enzyme Kinetics, Biochim Biophys
Acta., 1831(1), 139-46.
- Fells,
J.I., Lee, S.C., Fujiwara, Y., Norman, D.D., Lim, K.G., Tsukahara, R., Liu, J.,
Patil, R., Miller, D.D., Kirby, R.J., Nelson, S., Seibel, W., Papoian, R.,
Parrill, A.L., Baker, D.L., Bittman, R., and Tigyi, G., (2013) Hits of a High-Throughput Screen Identify
the Hydrophobic Pocket of Autotaxin/Lysophospholipase D as an Inhibitory
Surface, Mol. Pharmacol.,
84(3), 415-424.
- Norman,
D.D., Ibezim, A., Scott, W.E., White, S., Parrill, A.L., and Baker, D.L., (2013) Autotaxin
Inhibition: Development and Application
of Computational Tools to Identify Site-Selective Lead Compounds, Bioorg.
& Med. Chem., 21(17),
5548-5560.
- Fells, J.I., Lee, S.C., Norman, D.D., Tsukahara, R., Kirby, J.R., Nelsen,
S., Seibel, W., Papoian, R., Patil, R., Miller, D.D., Parrill, A.L., Pham, T., Baker, D.L., Bittman, R. and
Tigyi, G., (2014) Targeting the Hydrophobic Pocket of Autotaxin with Virtual
Screening of Inhibitors Identifies a Common Aromatic Sulfonamide Structural
Motif, FEBS J., 281(4), 1017-1028.
- Miller, D.D., Tigyi, G., Dalton, J.T., Sardar, V.M., Elrod, D.B., Xu, H., Baker, D.L., Wand, D., Lilliom, K., Fischer, D.J., Virag, T., Nusser, N., LPA Receptor Agonists and Antagonists and Methods of Use", US patent #6,875,757, 4/5/2005.
- Parrill, A.L., Baker, D.L., and
Montedonico, L., “Mechanism-Based Inactivators of Autotaxin”, US Patent #8,022,239,
issued 9/20/2011.
- Parrill-Baker, A.L., and Baker, D.L., “Autotaxin
Inhibitors”, US Patent #8,268,891, 9/18/2012.
- Parrill, A.L., Baker, D.L., and North,
E.J. “Novel Diverse Lead Compound
Autotaxin Inhibitors”, US Patent #8,343,934, 1/1/2013.
- Parrill, A.L.,
Baker, D.L., and Hoeglund, A., “Pipemidic Acid Derivative Autotaxin Inhibitors”,
US Patent #8,487,371, 7/30/2013.
- Ragle, L.E., Baker, D.L., and Parrill, A.L., (2016) Structure-activity relationships of autotaxin inhibition. Current Topics in Biochemical Research, 17, 1-18.
- Ragle, L.E., Palanisamy, D.J., Joe, M.J., Stein, R.S., Norman, D.D., Tigyi, G., Baker, D.L., and Parrill, A.L., (2016) Discovery and synthetic optimization of a novel scaffold for hydrophobic tunnel-targeted autotxain inhbition, Bioorg. & Med. Chem., 24(19), 4660-74.
- Banerjee S., Norman D.D., Lee S.C., Parrill A.L., Pham T.C., Baker D.L., Tigyi G.J., and Miller D.D. (2017) Highly Potent Non-Carboxylic Acid Autotaxin Inhibitors Reduce Melanoma Metastasis and Chemotherapeutic Resistance of Breast Cancer Cells, J Med. Chem. 60 (4), 1309-1324.
- Gacasan,
S., Baker, D.L., and Parrill, A.L., (2017) G Protein-Coupled Receptors: The
Evolution of Structural Insight, AIMS Biophysics, 4(3): 491-527.
- Castleman, P.N., Sears, C.K., Cole, J.A., Baker, D.L., and Parrill, A.L., (2019) GPCR Homology Model Template Selection Benchmarking: Global Versus Local Similarity Measures. J. Mol. Graph. & Model. 86:235-246.
- Wink, L, H., Cole J.A., Baker, D.L., and Parrill, A.L., (2019) A Benchmark Study of Loop Modeling Methods Applied to G Protein-Coupled Receptors. J. Computer-Aided Mol. Design 33:573-595.
- Jennings, J.A., Baker, D.L., Awais, R. Harrison, Z., and Raji, B., Controlling Biofilms with Cyclopropanated Fatty Acids. US Patent #11,311,506, 4/26/2022.
- Szwabowski, G.L., Castleman, P.N., Sears, C.K., Wink, L.H., Cole, J. A., Baker, D.L., and Parrill, A.L., (2020) Benchmarking GPCR Homology Model Template Selection in Combination with De Novo Loop Generation. J. Computer-Aided Mol. Design, 34:1027-1044.
- Harrison, Z. L., Bumgardner, J.D., Fujiwara, T., Baker, D.L., and Jennings, J.A., (2021) In Vitro Evaluation of Loaded Chitosan Membranes for Pain Relief and Infection Control. J. Biomed. Mater Res. 1-9.
- Harrison, Z.L., Awais, R., Harris, M.A., Raji, B., Hoffman,
B.C., Baker, D.L., and Jessica A. Jennings, J.A., (2021) 2-Heptylcyclopropane-1-Carboxylic
acid Disperses and Inhibits Bacterial Biofilms. Front. Microbiol. 12, 645180.
- Wells, C.M., Coleman, E.C., Yeasmin, R., Harrison, Z.L., Kurkula, M., Baker, D.L., Bumgardner, J.D., Fujiwara, T., and Jennings, J.A., (2021) Synthesis and Characterization of 2-Decenoic Acid Modified Chitosan for Infection Prevention and Tissue Engineering. Marine Drugs, 19, 556.
- Castleman, P., Szwabowski, G. Bowman, D., Cole, J.A., Parrill, A.L.,
and Baker, D.L., (2022) Ligand-Based G Protein Coupled Receptor Pharmacophore Modeling: Assessing
the Role of Ligand Function in Model Development, J.
Computer-Aided Mol. Design, 111: 108107.
- Thomas, B.N, Parrill,
A.L., and Baker, D.L., (2022) Self-docking and Cross-docking Simulations of G Protein-Coupled
Receptor-Ligand Complexes: Impact of
Ligand Type and Receptor Activation State,
J. Computer-Aided Mol. Design, 112: 108119.
- Szwabowski, G.L.,
Baker, D.L., Parrill, A.L., (2023) Application of Computational Methods
for Class A GPCR Ligand Discovery, J Mol Graph & Modeling, 121: 108434.
-
Szwabowski, G.L., Cole, J.A., Baker, D.L.,
Parrill, A.L., (2023) Structure-based Pharmacophore Modeling 1. Automated Random Pharmacophore Model Generation,
J Mol Graph & Modeling 121: 108429.
-
Szwabowski, G.L.,
Daigle, B.J., Baker, D.L., Parrill, A.L., (2023) Structure-based
Pharmacophore Modeling 2. Developing a Novel Framework for Structure-based
Pharmacophore Model Generation and Selection, J Mol Graph & Modeling, 122: 108488.
Presentations
- Baker, D.L. and Liebler, D.C., Direct analysis of lipid peroxidation products by GC/ECD. 33rd Society of Toxicology Meeting, 1994.
- Baker, D.L. and Liebler, D.C., Cigarette smoke oxidation of b-carotene: isolation and characterization of nitro-b-carotene. 14th Mountain West Society of Toxicology Meeting, 1996.
- Baker, D.L., Rael, L.T., and Liebler, D.C., Interactions between b-carotene and cigarette smoke in vitro. 87th American Association for Cancer Research Meeting, 1996.
- Baker, D.L. and Liebler, D.C., Cigarette smoke oxidation of b-carotene in model systems. 88th American Association for Cancer Research Meeting, 1997.
- Liebler, D.C. and Baker, D.L., Antioxidant and prooxidant interactions of b-carotene with cigarette smoke. 36th Society of Toxicology Meeting, 1997.
- Baker, D.L. and Tigyi, G.J., Analysis of gylcerol-3-phosphates in human serum by electrospray ionization mass spectrometry. 33rd Southeastern Regional Lipid Conference, 1998.
- Parrill, A.L., Baker, D.L., Wang, D., Fischer, D.J., van Brocklyn, J., Spiegel, S., and Tigyi, G.J., Structural features of EDG-1 receptor-ligand complexes revealed by computational modeling and mutagenesis. New York Academy of Sciences Conference on Lysophospholipids and Eicosinoids in Cancer and Neurodegenerative Diseases, 1999.
- Baker, D.L., Umstodt, E.S., Desiderio, D.M., and Tigyi, G.J., Quantitative analysis of lysophosphatidic acid in human blood fractions. New York Academy of Sciences Conference on Lysophospholipids and Eicosinoids in Cancer and Neurodegenerative Diseases, 1999.
- Bautista, D.L., Baker, D.L., Lorincz, Z., Wang, D., Fischer, D.J., van Brocklyn, J., Spiegel, S., Tigyi, G.J., and Parrill, A.L., Dynamic modeling of EDG1 receptor structural changes induced by site-directed mutations. 219th American Chemical Society Meeting, 2000.
- Sano, T., Baker, D., Wada, A., Yatomi, Y., Kobayashi, T., Igarashi, Y., and Tigyi, G., Multiple different mechanisms linked to platelet activation generate lysophosphatidic acid and sphingosine-1-phosphate. FASEB Summer Research Conference: Lysophospholipids and Related Bioactive Lipids in Biology and Disease, 2001.
- Bautista, D., Fischer, D., Nusser, N., Virag, T., Wang, D., Baker, D., Tigyi, G, and Parrill, A., Computational studies of a lysophosphatidic acid receptor antagonist. FASEB Summer Research Conference: Lysophospholipids and Related Bioactive Lipids in Biology and Disease, 2001.
- Baker, D., Morrison, P., Miller, B., Payne, T., Tolley, B., Miller, D., Desiderio, D., Moolenaar, W., and Tigyi, G., Quantitative analysis of lysophosphatidic acid molecular species in plasma and ascitic fluid from ovarian cancer patients. FASEB Summer Research Conference: Lysophospholipids and Related Bioactive Lipids in Biology and Disease, 2001.
- Rother, E., Brandl, R., Baker, D.L., Tigyi, G., and Siess, W., Subtype-selective antagonists of lysophosphatidic acid receptors inhibit platelet shape change induced by mildly oxidized LDL and the lipid core of athersclerotic plaques. American Heart Association Meeting, 2002.
- Zhang, C., Baker, D.L., Johnson, L.R., Balazs, L., McIntyre, T.M., Xu, Y., Prestwich, G.D., and Tigyi, G., Lysophosphatidic acid induced neointima formation. FASEB Summer Research Conference: Lysophospholipids and Related Bioactive Lipids in Biology and Disease, 2003.
- Baker, D., Cseh, S., Lu, X., Byun, H., Bittman, R., and Tigyi G., Sphingosine-1-phosphate photoaffinity labels: synthesis, characterization, and application. FASEB Summer Research Conference: Lysophospholipids and Related Bioactive Lipids in Biology and Disease, 2003.
- Lu, X., Cseh, S., Baker, D.L., Byun, H., Tigyi, G, and Bittman, R., Photoactivatable analogues of sphingosine-1-phosphate: synthesis and binding protein targets. 226th American Chemical Society Meeting, 2003.
- Sardar, V., Yuan, H., Allison, P., Chea, S., Kaminsky, J., Tsukahara, T., Tsukahara, R., Yasuda, S., Fujiwara, Y., Baker, D.L., Tigyi, G., and Parrill, A.L., Molecular insights into lysophosphatidic acid receptor agonism. BioScience2005, 2005.
- Fujiwara, Y., Sardar, V., Tokumura, A., Baker, D.L., Murakami-Murofushi, K., Parrill, A.L., and Tigyi, G., Identification of residues responsible for ligand recognition and regioisomeric selectivity of LPA receptors expressed in mammalian cells. FASEB Summer Research Conference: Lysophospholipid Mediators in Health and Disease, 2005.
- Baker, D.L., Pigg, K.R., Tsukahara, R., Tigyi, G., Parrill, A.L., Li, Z. and Bittman, R., Synthesis, evaluation and application of benzophenone analogs of lysophosphatidic acid and alkyl glycerophosphate. FASEB Summer Research Conference: Lysophospholipid Mediators in Health and Disease, 2005.
- Howard, A.L., Baker, D.L., and Parrill, A.L., Spectroscopic and Functional Characterization of Human NPP6. FASEB Summer Research Conference: Lysophospholipid Mediators in Health and Disease, 2007.
- North, E.J., Baker, D.L., and Parrill, A.L., Synthesis and Evaluation of LPC Analogues for Autotaxin Substrate Characterization. FASEB Summer Research Conference: Lysophospholipid Mediators in Health and Disease, 2007.
- Tsukahara, T., Tsukahara, R., Cheng, Y.-H., Zhang, C., Balazs, L., Du, G., Frohman, M.A., Baker, D.L., Parrill, A.L., and Tigyi, G., Cyclic Phosphatidic Acid is a Novel Second Messenger and Negative Regulator of the Nuclear Hormone Receptor PPAR-gamma. FASEB Summer Research Conference: Lysophospholipid Mediators in Health and Disease, 2007.
- Fujiwara Y., Baker D.L., Uchiyama A., Mukai M., Pigg K.R., Tsukahara R., Kobayashi S., Murofushi H., Koh E., Bandle R.W., Byun H.S., Bittman R., Fan D., Murph M., Mills G.B., Kawai N., Inoue M., Enoki S., Tanaka Y., Niki T., Kobayashi T., Murakami-Murofushi K., Tigyi G., Carba Analogs of Cyclic Phosphatidic Acid Inhibit Autotaxin Activity, Tumor Cell Migration, Invasion And Metastasis In Vitro And Vivo. FASEB Summer Research Conference: Lysophospholipid Mediators in Health and Disease, 2007.
- North, E.J., Baker, D.L. and Parrill, A.L., Synthesis and Evaluation of Lysophosphatidylcholine Analogs as Tools to Determine Crucial Autotaxin Substrate Characteristics. 59th Annual Southeast Regional Meeting of the American Chemical Society (SERMAS) 2007.
- Hoeglund, A.B., Parrill, A.L., and Baker, D.L., Screening and Identification of New Classes of Autotaxin (ATX) Inhibitors by Computational Modeling. Keystone Symposia on Computer-Aided Drug Design, 2008
- North, E.J., Baker, D.L., and Parrill, A.L., Autotaxin Structure Activity Relationships Identified through Lysophosphatidylcholine Analogs. 64th Annual Southwest Regional Meeting of the American Chemical Society, 2008.
- Howard-Shearer, A.L., Baker, D.L., and Parrill, A.L., NPP6 Model Validation by Computational Docking and Mutagenesis. 64th Annual Southwest Regional Meeting of the American Chemical Society, 2008.
- North, E.J., Baker, D.L., and Parrill, A.L., Virtual and Combinatorial Advances in the Identification of Bioavailable Autotaxin Inhibitors. 60th Annual Southeast Regional Meeting of the American Chemical Society, 2008.
- Howard-Shearer, A.L., Baker, D.L. and Parrill, A.L., Computational and Mutagenic Studies of NPP6. 60th Annual Southeast Regional Meeting of the American Chemical Society, 2008.
- Breland, D.C., Baker, D.L. , Parrill, A.L., and Webster, C.E., Computational Model Reveals Intermediate in Catalytic Mechanism of Xac Nucleotide Pyrophosphatase/ Phosphodiesterase. 60th Annual Southeast Regional Meeting of the American Chemical Society, 2008.
- Montedonico, L.E., Parrill, A.L., and Baker, D.L., Design and Biological Evaluation of Mechanism-Based Autotaxin Inhibitors. 60th Annual Southeast Regional Meeting of the American Chemical Society, 2008.
- Wanjala, I., Parrill, A.L., and Baker, D.L., Computational and Experimental Approaches for the Analysis of Alkaline Sphingomyelinase (Alk-SMase/NPP7). 60th Annual Southeast Regional Meeting of the American Chemical Society, 2008.
- Bearden, K. and Baker, D.L., Absolute Quantitative Analysis of Lysophosphatidic Acid G Protein-Coupled Receptors by Liquid Chromatography-Mass Spectrometry. 60th Annual Southeast Regional Meeting of the American Chemical Society, 2008.
- Pham, T.T., Hoeglund, A., Baker, D.L., and Parrill, A.L., Pharmacological Characterization of Candidate Drug-Like Autotaxin Inhibitors. 60th Annual Southeast Regional Meeting of the American Chemical Society, 2008.
- Pham, T.T., Parrill, A.L., and Baker, D.L., New Insights into the Structure and Functions of the Beta Isoform of Autotaxin. FASEB Summer Research Conference: Lysophospholipid Mediators in Health and Disease, 2009.
- Hoeglund, A.B., Pham, T.T., Howard, A.L., Wanjala, I.W., Parrill, A.L., and Baker, D.L., Pharmacological and Mechanistic Characterization of Non-Lipid Autotaxin Inhibitors. FASEB Summer Research Conference: Lysophospholipid Mediators in Health and Disease, 2009.
- Howard, A.L., Wanjala, I.W., Pham, T.T., Parrill, A.L., and Baker, D.L., Experimental Characterization of Recombinant Lysophospholipase C (NPP6, NPP7) and Lysophospholipase D (NPP2) Enzymes. FASEB Summer Research Conference: Lysophospholipid Mediators in Health and Disease, 2009.
- North, E.J., Pham, T.T., Baker, D.L., and Parrill, A.L., Pharmacophore Development and Application in the Identification of Drug-like Autotaxin Inhibitors. FASEB Summer Research Conference: Lysophospholipid Mediators in Health and Disease, 2009.
- Breland, D., Parrill, A.L., Baker, D.L., and Webster, C.E., The Phosphoryl Transfer Mechanism in Xac Nucleotide Pyrophosphatase/ Phosphodiesterase: A Computational Study. 61st Annual Southeast Regional Meeting of the American Chemical Society, 2009.
- Parrill, A.L.,
North, E.J., Hoeglund, A., Bostic,
H.E., Best, M.D., and Baker, D.L., Discovering
autotaxin inhibitors. Bioactive Lipids in Cancer, Inflammation and Related Diseases, 11th International Conference, 2009.
- Wanjala, I.W., Parrill, A.L., and Baker, D.L., “Structural
and Functional Characterization of Alkaline Sphingomyelinase (NPP7)”, 38th
Great Lakes Regional Meeting of the American Chemical Society, 2009.
- Baker, D.L.,
Wanjala, I.W., Pham, T.C., Howard, A.L., Cox, J.J., and Parrill, A.L., Structural
and Functional Analysis of Phospholipid-Specific Nucleotide Pyrophosphatase/
Phosphodiesterase Isoforms. Experimental
Biology, 2010.
- Pham, T.C.,
Wanjala, I.W., Howard, A.L., Parrill, A.L., and Baker, D.L., Insights
into the structure and function of lipid preferring Nucleotide Pyrophosphotase Phosphodiesterase
isoforms. Joint Meeting of the 66th
Southwest and 62nd Southeast Regional American Chemical Societies, 2010.
- Baker, D.L.,
Wanjala, I.W., and Parrill, A.L., Characterization of substrate specifying
determinants of Nucleotide Pyrophosphatase Phosphodiesterase Seven. Joint
Meeting of the 66th Southwest and 62nd Southeast Regional
American Chemical Societies, 2010.
- Bearden, K., and Baker, D.L., “Absolute
Quantitative Analysis of Lipid Preferring Nucleotide Pyrophosphatase
Phosphodiesterase Isoforms by Stable Isotope Dilution LC-MS”, Joint Meeting of
the 66th Southwest and 62nd Southeast Regional American
Chemical Societies, 2010.
- Parrill, A.L., North, E.J., Hoeglund, A., Bostic, H.,
Best, M.D., and Baker, D.L., “Computer-Aided Discovery of Autotaxin Inhibitors”,
240th National Meeting of the American Chemical Society, 2010.
- Bolen, A.L., Naren, A.P., Yarlagadda, S.,
Beranova-Giorgianni, Chen, S.L., Norman, D.D., Baker,
D.L., Best, M.D., Rowland, M.M., Sano, T., Tsukahara, T., Liliom, K.,
Igarashi, Y., and Tigyi, G., The
Phospholipase A1 Activity of Acyl-Protein Thioesterase Links Platelet
Activation to LPA Production During Blood Clotting. Experimental Biology, 2011.
- Tsukahara, R., Tsukahara, T., Fujiwara, Y., Yue, J.,
Cheng, Y., Guo, H., Bolen, A.L., Zhang, C., Balazs, L., Re, F., Du, G.,
Frohman, M.A., Baker, D.L.,
Parrill, A.L., Murakami-Murofushi, K., and Tigyi, G., The PLD2 Product Cyclic Phosphatidic Acid Is a Novel Lipid Second
Messenger that Inhibits the Nuclear Hormone Receptor PPARγ. Experimental Biology, 2011.
- Parrill, A.L., Howard, A.L., Wanjala, I.W., and Baker, D.L., Insights into
substrate recognition and discrimination by the phospholipid-preferring
Nucleotide Pyrophosphatase/Phosphodiesterase isoforms. 241st National Meeting of the
American Chemical Society, 2011.
- Baker, D.L.,
Mize, C., Abbott, A., and Parrill, A.L., Design and application of
computational tools for the rational design and discovery of
Autotaxin inhibitors. 241st
National Meeting of the American Chemical Society, 2011. - Pham, T.C., Wanjala, I., Howard, A., Breland, D.,
DeYonker, N.J., Webster, C.E., Parrill, A.L., Baker, D.L., “Characterizing the
Structure and Function of Lipid Preferring Nucleotide Pyrophosphase
Phosphodiesterases using Computational and Experimental Tools”, 63rd
Meeting of the Southeast Regional of the American Chemical Society, 2011.
- Sparks, M., Pham, T.C., Baker, D.L., “Comparison of
Multiple Expression Systems for the Study of Sphingosine Kinase 1”, 63rd
Meeting of the Southeast Regional of the American Chemical Society, 2011.
- Norman, D.D., Scott, W.E., White, S., Ibezim, A.,
Parrill, A.L., Baker, D.L., “ATX Inhibition:
Development of Computational Tools to Identify Hydrophobic Tunnel
Targeted Leads”, 63rd Meeting of the Southeast Regional of the
American Chemical Society, 2011.
- Mize, C.D., Abbott, A.M., Gacasan, S.B., Parrill, A.L.,
Baker, D.L., “Ligand-Based Autotaxin Pharmacophore Models Reflect
Structure-Based Docking Results”, 63rd Meeting of the Southeast
Regional of the American Chemical Society, 2011.
- Sparks, M.A., Pham, T.C., Baker, D.L.,”
Functional Analysis of Sphingosine Kinase 1”, 68th Meeting of
Southwest Regional American Chemical Society, 2012.
- Ragle, L.E., Baker, D.L., Parrill, A.L.,
Structure-based Pharmacophore Development for Hydrophobic Autotaxin
Inhibition”, 68th Meeting of Southwest Regional American Chemical
Society, 2012.
- Scott, W.E., and Baker, D.L., “Enzymatic
Analysis of the LPLD vs. LPLC Activity of Autotaxin”, 68th Meeting
of Southwest Regional American Chemical Society, 2012.
- Baker, D.L., Norman, D.D., Ibezim, A.,
Scott, W.E., White, S., Parrill, A.L., “Autotaxin Inhibition: Development of Computational Tools to
Identify Site-Selective Leads”, 68th Meeting of Southwest Regional
American Chemical Society, 2012.
- Pham, T.C., Sparks, M.A., Baker, D.L.,
“Sphingosine Kinase 1: Insights into Structure
and Function”, 64th Meeting of the Southeast Regional American
Chemical Society, 2012.
- Baker,
D.L., Pham, T.C., and Sparks, M.A., “Examination of the Structure and Function
of Sphingosine Kinase 1”, 245th National Meeting of the American
Chemical Society, 2013.
- Baker,
D.L., “Implementation of a Hybrid, Reverse-Instruction Model in CHEM 3511,
Foundations of Bioorganic Chemistry”, 245th National Meeting of the
American Chemical Society, 2013.
- Pham, T.T. and Baker, D.L., Functional Analysis of Diacylglycerol Kinase-Beta, 66th Meeting of the Southeast Regional American
Chemical Society, 2014.
- Ragle, L.E., Palanisamy, D.J., Baker, D.L., and Parrill, A.L., Synthetic Optimization of a Novel Scaffold for Hydrophobic Tunnel-Targeted Autotaxin Inhibition. 66th Meeting of the Southeast Regional American
Chemical Society, 2014.
- McDonald, J.W., Raji, B.A., Parrill, A.L., and Baker, D.L., Computational Discovery and Synthesis of Novel Fluorogenic Substrate(s) for Sphingosine Kinase 1: An Approach to High-Throughput Assay Development, 66th Meeting of the Southeast Regional American
Chemical Society, 2014.
- Pham, T.C., Gacasan, S., and Baker, D.L., "Analysis of the Bisubstrate Kinetics of Sphingosine Kinase-1 Inhibitors", Joint Meeting of the 71stSouthwest and 67th Southeast Regional American Chemical Societies, 2015.
- Pham, T.C. and Baker, D.L., "Analysis of Site Directed Mutants of Diacylglycerol Kinase-Beta by LC-MS/MS and Bisubstrate Kinetics", Joint Meeting of the 71stSouthwest and 67th Southeast Regional American Chemical Societies, 2015.
- Pham, T.C. and Baker, D.L., "Analysis of Site-Directed Mutants of Sphingosine Kinase-1 by LC-MS/MS and Bisubstrate Kinetics", Joint Meeting of the 71stSouthwest and 67th Southeast Regional American Chemical Societies, 2015.
- Ragle, L. Baker, D., and Parrill-Baker, A. "Expanded Structure-Activity Relationship Analysis of Small Molecule Autotaxin Inhibitors", Joint Meeting of the 71stSouthwest and 67th Southeast Regional American Chemical Societies, 2015.
- Yarbro, J.M., Fathi, E., Ziebarth, J.D., Gacasan,S.B., Baker, D.L., Parrill,A.L., and
Homayouni, R., "Characterization of APP and NAD(P)H
Interactions with Nipsnap1, a Novel Mitochondrial Protein", Alzheimer’s Association
International Conference, 2018.
- Castleman, P.N., Cole, J.A., Baker,
D.L., and Parrill, A.L., "Homology Model Template Selection Benchmarking: Global Versus Local Similarity Measures", National Meeting of the American Chemical Society, 2018.
- Castleman, P.N., Cole, J.A., Baker,
D.L., and Parrill, A.L., "Homology Model Template Selection
Benchmarking: Global Versus Local Similarity Measures", 74th Annual
Meeting of the Southwest Region of the American Chemical Society, 2018.
- Sears, C.K., Parrill, A.L., and Baker,
D.L., "Development of a G Protein-Coupled Receptor Deorphanization Protocol: Application to GPR37L1", 74th Annual
Meeting of the Southwest Region of the American Chemical Society, 2018.
- Awais, R., Harrison, Z., Raji, B., Murali, V., Bumgardner, J., Baker, D., and Jennings, J., "Cis-2-Decenoic Acid Loaded into Acylated Chitosan Membranes Inhibit Bacterial Biofilms", 8th Annual Meeting of the American Society for Microbiology Biofilms Conference, 2018.
- Harrison, Z., Awais, R., Raji, B., Baker, D., Jennings, J., "Cyclopropyl Analog of Cis-2-Decenoic Acid Inhibits and Disperses S. aureus Biofilm", Annual Meeting of the Orthopaedic Research Society, 2019.
- Awais, R., Harrison, Z., Raji, B., Murali, V., Bumgardner, J., Baker, D., Jennings, J., "2-Heptylcyclopropane-1-Carboxylic Acid Loaded Acylcated Chitosan Membranes Inhibit Bacterial Biofilms", Annual Meeting of the Society for Biomaterials, 2019.
- Castleman, Paige N.;
Szwabowski, Gregory L.; Baker, D.L.; Parrill, Abby L. “Pharmacophore
benchmarking: The role of ligand function in pharmacophore development.” 2019
Southeast Regional Meeting of the American Chemical Society. Savannah, GA. 2019.
- Szwabowski,
G.L.; Castleman, P.N.; Sears, C.K.; Wink, L.H.; Cole, J.A.; Baker, D.L.;
Parrill, A.L. “Benchmarking GPCR homology model template selection in
combination with de novo loop generation”, 2019 Southeastern Regional Meeting
of the American Chemical Society, 2019.
- Awais, R.;
Harrison, Z.L.; Raji, B.; Murali, V.P.; Bumgardner, J.D.; Baker, D.L.; Jennings,
J.A. "2-Heptylcyclopropane -1-carboxylic acid loaded acylated chitosan
membranes inhibit bacterial biofilms." Society for Biomaterials Annual
Meeting, Seattle, WA. 2019.
- Harrison,
Z.L.; Awais, R.; Raji, B.; Baker, D.L.; Jennings, J.A. "Cyclopropyl analog
of cis-2-decenoic acid inhibits and disperses S. aureus biofilm."
Orthopaedic Research Society, Austin, TX. 2019.
- Hannie, K.D.; Parrill, A.L.; Baker, D.L.,
“Computational and Experimental Filtering of Potential Therapeutics using ADMET
Properties,” 258th American Chemical Society National Meeting and Exposition.
San Diego, CA. August 26-28th, 2019.
- Harrison,
Z.L.; Awais, R.; Murali, V.P.; Bumgardner, J.D.; Fujiwara, T.; Baker, D.L.; Jennings,
J.A. "Achieving wound coverage, infection prevention, and pain relief
through acylated electrospun chitosan membranes " 9th International DoD
State-of-the-Science Meeting: Burn Injury, Washington, DC, 2020.
- Harrison,
Z.L.; Awais, R.; Murali, V.; Bumgardner, J.D.; Fujiwara, T.; Baker, D.L.; Jennings,
J.A. "Acylated electrospun chitosan membranes for wound coverage,
infection prevention, and pain relief." World Congress of Biomaterials,
Glasgow Scotland, 2020.
- Castleman, P.N.; Szwabowski, G.L.;
Bowman, D.; Cole, J.A.; Parrill-Baker, A.L.; Baker, D.L.“Pharmacophore
benchmarking: The role of ligand function in pharmacophore development.” 2020
Rocky Mountain Regional Meeting of the American Chemical Society. November 2020.
AWARD: Division
of Medicinal Chemistry Award for presentation.
- Szwabowski, G.L.; Parrill, A.L.; Baker, D.L., “Automated construction of
fragment-based pharmacophores to elucidate novel GPCR ligands”, Rocky Mountain
Regional Meeting of the American Chemical Society, November, 2020
- Dyer, C.; Parrill, A.L.; Baker, D.L., “Statistical Analysis of
Protein-Protein Comparison Methods.” Rocky Mountain Regional Meeting of the
American Chemical Society, November, 2020. AWARD: Stanley C.
Israel Regional Award for Advancing Diversity in the Chemical Sciences
- Hoffman, B. and Baker, D.L., “Quantitative
analysis of diffusible signaling factors using negative ion liquid
chromatography electrospray ionization mass spectrometry (HPLCESI-MS)” Rocky
Mountain Regional Meeting of the American Chemical Society, November, 2020.
- Wiley, E. R. and
Baker, D. L., “Modular synthesis and characterization of diffusible signal
factor analogs for the study of structure activity relationships and mechanism
of action.” Rocky Mountain Regional Meeting of the American Chemical
Society. Virtual. November 2020.
- Thomas, B.N.; Parrill, A.L.; Baker, D.L.,
“Self-docking and cross-docking simulations of G protein-coupled
receptor-ligand complexes: analysis of ligand type and receptor activation
state”, Rocky Mountain Regional Meeting of the American Chemical Society,
November, 2020.
- Griffing, M.; Baker, D.L.; and Parrill, A.L.,
“Systematic Analysis of Ligand Binding Site Locations Within Crystalized
GPCR Complexes”, Rocky Mountain Regional Meeting of the American Chemical Society,
November, 2020.
- Ruddick, K.R.; Elayan, A.M.; Nelson, H.A.; Lashet, C.; Hanson, J.; Parrill, A.L.; Cole, J.A.; Baker, D.L., "NanoLuc (NLuc) complementation assay elucidates role of specific G-proteins in GPR88 signaling" Experimental Biology National Meeting 2021. CHOSEN for additional GPCR colloquium by ASPET, ASBMB, and APS.
- Szwabowski, G.L.; Griffing, M.C.; Guerrero, M.; Ruddick, K.R.;
Cole, J.A.; Baker, D.L., Parrill A.L., “A Method of Automated Pharmacophore
Model Generation Using Multiple Copy Simultaneous Search” National American
Chemical Society Meeting, August 2021.
- Orellana, K.*; Dyer, C.*; Parrill, A.L.; Baker, D.L., “Statistical
Analysis of Protein Similarity Measures?” National American Chemical Society
Meeting, August 2021.
- Hoffman, B.*; Wiley*, E. R.; Baker, D.L., “Synthesis and
Quantitative Analysis of Diffusible Signal Factor Analogs as Antibiofilm Agents”
National American Chemical Society Meeting, August 2021.
- Dyer, C.; Parrill, A.L.; Baker, D.L., “Hydrophobic Surface
Patch Disruption to Produce Water-Soluble G-Protein Coupled Receptor Analogs” Southeast
Regional Meeting of the American Chemical Society, November 2021.
- Dyer, C.*; Orellana, K.*; Parrill, A.L.; Baker, D.L., “Statistical
Analysis of Protein Similarity Measures”, Southeast Regional Meeting of the
American Chemical Society, November 2021.
- Hoffman, B. and Baker D.L., “Quantitative analysis of fatty
acid diffusible signaling factors by HPLC-ESI-MS” Southeast Regional Meeting of
the American Chemical Society, November 2021.
- Wiley, E.R. and Baker, D.L., “Synthesis and characterization
of novel diffusible signal factor analogs for analysis of structure activity
relationships” Southeast Regional Meeting of the American Chemical Society,
November 2021.
- Szwabowski, G.L.; Parrill, A.L.; Baker, D.L., “A method of
automated, score-based pharmacophore generation using Multiple Copy
Simultaneous Search” Southeast Regional Meeting of the American Chemical
Society, November 2021.
- Szwabowski, G.L., Parrill, A.L., and Baker, D.L., "A Method for Automated Pharmacophore Model Generation Using Multiple Copy Simultaneous Search". National Experimental Biology Meeting, April 2022.
- Szwabowski, G.L., Parrill, A.L., Baker, D.L., "Automated, Score-Based Pharmacophore Generation Using Multiple Copy Simultaneous Search" National Experimental Biology Meeting, April 2022.
-
Hoffman, B., Jennings, J.A., Baker D.L.,
“Synthesis and quantitative analysis of diffusible signaling factors, for
determination of structure-activity relationships and structural stability” National
Meeting of the American Chemical Society, August 2022.
-
Wiley, E.R., Garner, C.M., Jennings, J.A., Baker,
D.L., “Stereoselective synthesis and characterization of novel
diffusible signal factor analog enantiomers” National Meeting of the American
Chemical Society, August 2022.
- Harrison, Z., Bush, J., Perez, F., Bumgardner, J., Fujiwara, T., Baker, D.L., Jennings, J.A., "Silanized Titanium for Delivery of Hydrophobic Therapeutic in Aqueous Environments" Society for Biomaterials: Biomaterial Applications Meeting, October 2022.
- Coleman, E., Reaño, I.B., Wiley, E.R., Baker, D.L., Jennings, J.A., "Hydroxyapatite Loaded with
2-heptylcyclopropane-1-carboxylic Acid Inhibits S. Aureus Biofilm Formation" Society for Biomaterials: Biomaterial Applications Meeting, October, 2022.
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