Faculty and Staff Profiles

Brandt D. Pence
Assoc Professor, College of Health Sciences
Email: bdpence@memphis.edu
Office Location: 304 Elma Roane Fieldhouse
Profile

Lab group website: http://www.brandtpence.com


Education
  • Grad Cert Bioinformatics - University of Memphis - 2020
  • Ph.D. Exercise Physiology - University of Illinois Urbana-Champaign - 2012
  • B.A. Movement and Sport Science - Purdue University - 2007

Work Experience

  • Assistant Professor, Nutrition, School of Health Studies - University of Memphis - 2016-Present
  • Postdoctoral Research Associate, Department of Kinesiology and Community Health - University of Illinois Urbana-Champaign - 2012-2016
  • Graduate Research and Teaching Assistant, Department of Kinesiology and Community Health - University of Illinois Urbana-Champaign - 2007-2012
  • Undergraduate Laboratory Assistant, Department of Health and Kinesiology - Purdue University - 2006-2007
Honors/Awards
  • Selected for Summer Training Course in Experimental Aging Research - National Institute of Aging - 2019
  • Travel Award - Agilent Technologies - 2018
  • Postdoctoral Research Award - American Society for Nutrition - 2015
  • Outstanding Graduate Student Award - Midwest Chapter, American College of Sports Medicine - 2011
  • Early Career Research Award - International Society for Exercise and Immunology - 2011
  • Trainee Scholar Award - Psychoneuroimmunology Research Society - 2011

Teaching Experience

  • ESMS 4010/6010 - Supplements/Food/Drugs Health - University of Memphis
  • HLSC 4400 - Statistics for Health Studies - University of Memphis
  • HMSE 7010 - Research Methods in HSS - University of Memphis
  • NUTR 7000 - Sport Nutrition - University of Memphis
  • NUTR 7100 - Intro to Wet Lab Methods in Health Studies - University of Memphis
  • NUTR 7152 - Problems in Nutrition - University of Memphis
  • KIN 494 - Exercise and Disease - University of Illinois Urbana-Champaign
  • KIN 150 - Bioscience of Human Movement Laboratory - University of Illinois Urbana-Champaign
  • KIN 352 - Bioenergetics of Movement Laboratory - University of Illinois Urbana-Champaign

Student Advising/Mentoring

  • Postdoctoral Fellow - Russell Emmons, PhD -  
  • M.S. in Exercise Sport and Movement Science - Kierstin Davis - 2022
  • M.S. in Nutrition Science - Alexandria Griffin - 2022
  • M.S. in Clinical Nutrition - Christopher Branner - 2020
  • M.S. in Nutritional Science - Johnathan Yarbro - 2019
  • M.S. in Clinical Nutrition - Lindsey Hedrick - 2018

Support

  • SARS-CoV-2/COVID-19 Research CORNET Award - UTHSC/UofM - 50,000 - 2020-2021
  • Transformational Project Award - American Heart Association - 300,000 - 2019-2022
  • Nathan Shock Center Metabolomics Pilot Award - University of Washington - 10,000 - 2019-2020
  • AHA Institutional Research Enhancement Award - American Heart Association - 154,000 - 2018-2020
  • Foundation Research Endowment - American College of Sports Medicine - 10,000 - 2018-2019
  • Foundation Research Endowment - American College of Sports Medicine - 10,000 - 2014-2016
  • Grants-in-Aid of Research - Sigma Xi - 1,000 - 2012-2013
  • Student Research Project Award - American College of Sports Medicine Midwest Chapter - 500 - 2012-2013
  • Student Grant Program - Gatorade Sports Science Institute - 3,340 - 2009-2012
  • Foundation Student Grant - American College of Sports Medicine - 4,956 - 2009-2010
  • Agriculture and Food Technologies Research Cluster Pilot Grant - FedEx Institute of Technology - 10,000 - 2019-2020
  • Faculty Research Grant - School of Health Studies - 7,500 - 2019-2020
  • Faculty Research Grant - School of Health Studies - 7,500 - 2017-2018
Service
  • National Institutes of Health - Innate Immunity and Inflammation Study Section - 2020
  • National Science Foundation - CAREER Application Ad Hoc Review - 2019
  • NSERC (Canada) - Discovery Grant Review - 2019-2021
  • NSERC (Canada) - E.W.R Steacie Memorial Fellowship Reviewer - 2018
  • American Heart Association - Fellowship Immunology Grant Reviewer - 2017-2021
  • Gerontological Society of America - Annual Meeting Abstract Review - 2017-2018
  • American College of Sports Medicine - Research Review Committee - 2020-2023
  • American College of Sports Medicine - Ad Hoc Grant Review - 2020
  • American Society for Nutrition - Annual Meeting Abstract Review - 2016-2018
  • American Society for Nutrition - Emerging Leaders in Nutrition Science Competition Judge - 2017
  • National Conference on Undergraduate Research - Session Chair - 2017
  • National Conference on Undergraduate Research - Abstract Reviewer - 2016
  • CRC Press - Ad Hoc Book Proposal Review - 2020
  • University of Memphis - Search Committee for Clinical Assistant/Association Professor of Nutrition - 2019
  • University of Memphis - Search Committee for Research Assistant Professor of Nutrition - 2019
  • University of Memphis - Research Council Member - 2018-2022
  • University of Memphis - Institutional Animal Care and Use Committee - 2017-2020
  • University of Memphis - Chair, Search Committee for Assistant/Associate Professor of Nutrition - 2018
  • University of Memphis - Search Committee for Research Assistant Professor - 2018
  • University of Memphis - Planning Committee for PhD Program in SHS - 2017-2018
  • University of Memphis - Search Committee for Research Assistant Professor in Nutrition - 2017
  • University of Memphis - Student Research Forum Judge - 2018-2019
  • University of Illinois Urbana-Champaign - Judge, Nutrition Symposium Poster Presentations - 2015-2016
  • University of Illinois Urbana-Champaign - Member, Search Committee for Associate/Full Professor in Exercise Physiology - 2011
  • University of Illinois Urbana-Champaign - Exercise Physiology Concentration Representative, Kinesiology Graduate Student Association - 2008
  • Frontiers in Aging - Associate Editor - 2020-
  • Frontiers in Immunology - Associate Editor - 2020-
  • Frontiers in Nutrition - Associate Editor - 2020-
  • PLoS One - Academic Editor - 2018-
  • Frontiers in Immunology - Review Editor - 2017-2020
  • Frontiers in Nutrition - Review Editor - 2017-2020
  • 53 distinct peer-reviewed journals - Ad-Hoc Manuscript Review -  
Journal Articles
  • 42.    Pence BD. Atypical monocytes in COVID-19: Lighting the fire of cytokine storm? Journal of Leukocyte Biology 109: 7-8, 2021.

    41.    Pence BD, Yarbro JR, Emmons RS. Growth differentiation factor-15 is associated with age-related monocyte dysfunction. Aging Medicine [in press]

    40.    Yarbro JR, Emmons RS, Pence BD. Macrophage immunometabolism and inflammaging: Roles of mitochondrial dysfunction, cellular senescence, CD38, and NAD. Immunometabolism 2(3): 200026, 2020.

    39.    Pence BD. Fanning the flames of inflammaging: Impact of monocyte metabolic reprogramming. Immunometabolism 2(3): 200025, 2020.

    38.    Pence BD. Severe COVID-19 in aging: Are monocytes the key? Geroscience 42: 1051-1061, 2020.

    37.    Nieman DC, Pence BD. Exercise immunology: Future directions. Journal of Sport and Health Science 9(5): 432-445, 2020.

    36.    Yarbro JR, Pence BD. Classical monocytes from older adults maintain capacity for metabolic compensation during glucose deprivation and lipopolysaccharide stimulation. Mechanisms of Ageing and Development 183: 111146, 2019.

    35.    Sun Y, Pence BD, Wang SS, Woods JA. Effects of exercise on stress-induced attenuation of vaccination responses in mice. Medicine and Science in Sports and Exercise 51(8): 1635-1641, 2019.

    34.    Smith DL, Friedman N, Bloom SI, Armero WL, Pence BD, Fernhall B, Horn GP, Woods JA. Firefighting induces acute inflammatory responses that are not relieved by aspirin in older firefighters. Journal of Occupational and Environmental Medicine 61(7): 617-622, 2019.

    33.    Pence BD, Yarbro JR. Classical monocytes maintain ex vivo glycolytic metabolism and early but not later inflammatory responses in older adults. Immunity & Ageing 16: 3, 2019.

    32.    Mailing LJ, Allen JM, Pence BD, Rytych J, Sun Y, Bhattacharya TK, Park P, Cross TW, McCusker RH, Swanson K, Fahey GC, Rhodes JS, Kelley KW, Johnson RW, Woods JA. Behavioral response to fiber feeding is cohort dependent and associated with gut microbiota composition in mice. Behavioural Brain Research 359: 731-736, 2019.

    31.    Yarbro JR, Pence BD. Monocytes in aging and exercise. Exercise Medicine 2: 15, 2018.

    30.    Pence BD,Yarbro JR. Aging impairs mitochondrial respiratory capacity in classical monocytes. Experimental Gerontology 108: 112-117, 2018.

    29.    Pence BD, Ryerson MR, Bravo-Cruz AG, Woods JA, Shisler JL. Voluntary wheel running does not alter mortality to or immunogenicity of vaccinia virus in mice: A pilot study. Frontiers in Physiology 8:1123, 2018.

    28.    Pence BD, Bhattacharya TK, Park P, Rytych JL, Allen JM, Sun Y, McCusker RH, Kelley KW, Johnson RW, Rhodes JS, Woods JA. Long-term supplementation with EGCG and beta-alanine decreases mortality but does not affect cognitive or muscle function in aged mice. Experimental Gerontology 98: 22-29, 2017.

    27.    Pence BD, Bhattacharya TK, Park P, Rytych JL, Allen JM, Sun Y, McCusker RH, Kelley KW, Johnson RW, Rhodes JS, Woods JA. Dose-dependent decrease in mortality with no cognitive or muscle function improvements due to dietary EGCG supplementation in aged mice. Applied Physiology, Nutrition, and Metabolism 42(5): 495-502, 2017.

    26.    Klaren RE, Stasula U, Steelman AJ, Hernandez J, Pence BD, Woods JA, Motl RW.  Effects of exercise in a relapsing-remitting model of experimental autoimmune encephalomyelitis. Journal of Neuroscience Research 94(10): 907-914, 2016.

    25.    Cook MD, Allen JM, Pence BD, Wallig MA, Gaskins HR, Woods JA.  Exercise and gut immune function: Evidence of alterations in colon immune homeostasis and microbiome characteristics with exercise training.  Immunology and Cell Biology 94(2): 158-163, 2016.

    24.    Pence BD, Gibbons TE, Bhattacharya TK, Mach HC, Ossyra JM, Petr G, Martin SA, Wang L, Rubakhin SS, Sweedler JV, McCusker RH, Kelley KW, Rhodes JS, Johnson RW, Woods JA.  Differential effects of voluntary wheel running and a diet containing EGCG and ß-alanine on physical function and gene expression in skeletal muscle of aged mice. Applied Physiology, Nutrition, and Metabolism 41(2): 181-190, 2016.

    23.    Bhattacharya TK, Pence BD, Ossyra JM, Gibbons TE, Perez S, McCusker RH, Kelley KW, Johnson RW, Woods JA, Rhodes JS.  Dietary supplementation with (-)-Epigallocatechin-3-gallate and/or ß-Alanine does not enhance pro-cognitive or physical fitness effects of voluntary wheel running in young adult male BALB/cJ mice. Physiology & Behavior 145: 29-37, 2015.

    22.    Allen JM, Berg Miller ME, Pence BD, Whitlock K, Nehra V, Gaskins HR, White BA, Fryer JD, Woods JA.  Voluntary and forced exercise differentially alter the gut microbiome in C57Bl/6J mice. Journal of Applied Physiology 118(8): 1059-1066, 2015.

    21.    Woods JA, Pence BD.  Physical activity, exercise, and the immune system: Three lines of research that have driven the field. Kinesiology Review 4: 118-125, 2015.

    20.    Leckie RL, Oberlin LE, Voss MW, Prakash RS, Szabo-Reed A, Chaddock-Heyman L, Phillips SM, Gothe N, Mailey E, Vieria-Potter VJ, Martin SA, Pence BD, Lin M, Parasuraman R, Greenwood PM, Fryxell KJ, Woods J, McAuley E, Kramer AF, Erickson KI.  BDNF mediates improvements in executive function following a 1-year exercise intervention. Frontiers in Human Neuroscience 8: 985, 2014.

    19.    Gibbons TE*, Pence BD*, Petr G, Ossyra JM, Bhattacharya TK, Perez S, Martin SA, McCusker RH, Kelley KW, Rhodes JS, Johnson RW, Woods JA.  Voluntary wheel running, but not a diet containing EGCG and ß-alanine, improves learning and memory and hippocampal neurogenesis in aged mice. Behavioural Brain Research 272:131-140, 2014.

    18.    Markofski MM, Carrillo AE, Timmerman KL, Jennings K, Coen PM, Pence BD, Flynn MG.  Exercise training modifies ghrelin and adiponectin concentrations and is related to inflammation in older adults.  The Journals of Gerontology. Series A: Biological Sciences and Medical Sciences 69(6): 675-681, 2014.

    17.    Pence BD, Woods JA.  Exercise, obesity, and cutaneous wound healing: Evidence from rodent and human studies.  Advances in Wound Care 3(1): 71-79, 2014.

    16.    Cook MD, Martin SA, Williams C, Wallig MA, Pence BD, Woods JA.  Forced treadmill exercise training exacerbates inflammation and causes mortality while voluntary wheel training is protective in a mouse model of colitis.  Brain Behavior and Immunity 33: 46-56, 2013.

    15.    Thorum SC, Hester SN, Comstock SS, Monaco MH, Pence BD, Woods JA, Donovan SM.  Dietary (1,3/1,6)-ß-D-glucan decreases transforming growth factor ß expression in the lung of the neonatal piglet.  Nutrition Research 33(4): 322-331, 2013.

    14.    Martin SA, Pence BD, Greene R, Johnson S, Dantzer R, Kelley KW, Woods JA.  Voluntary wheel running has no effect on LPS-induced inflammation or sickness behavior in aged mice.  Brain Behavior and Immunity 29: 113-123, 2013.

    13.    Voss MW, Erickson KI, Prakash RS, Chaddock L, Kim JS, Alves H, Szabo A, White SM, Wojcicki TR, Mailey EL, Olson EA, Gothe N, Potter VV, Martin SA, Pence BD, Cook MD, Woods JA, McAuley E, Kramer AF.  Neurobiological markers of exercise-related brain plasticity in older adults. Brain Behavior and Immunity 28: 90-99, 2013.

    12.    Pence BD, DiPietro LA, Woods JA. Exercise speeds cutaneous wound healing rate in high-fat diet-induced obese mice.  Medicine and Science in Sports and Exercise 44(10): 1846-1854, 2012.

    11.    Hester SN, Thorum SC, Comstock SS, Monaco MH, Pence BD, Woods JA, Donovan SM.  Intestinal and systemic immune development are unaffected by dietary (1,3/1,6)-ß-D-glucan supplementation of neonatal piglets.  Clinical and Vaccine Immunology 19(9): 1499-1508, 2012.

    10.    Pence BD, Lowder TW, Keylock KT, Vieira Potter VJ, Cook MD, McAuley E, Woods JA.  Relationship between systemic inflammation and delayed-type hypersensitivity response to candida antigen in older adults.  PLoS One 7(5): e36403, 2012.

    9.      Pence BD, Hester SN, Donovan SM, Woods JA.  Dietary whole glucan particles do not affect antibody or cell-mediated responses to influenza virus vaccination in mice. Immunological Investigations 41(3): 275-289, 2012.

    8.      Anderson-Hanley C, Arciero PJ, Brickman AM, Nimon JP, Okuma N, Westen SC, Merz ME, Pence BD, Woods JA, Kramer AF, Zimmerman EA.  Exergaming and older adult cognition: A cluster randomized controlled trial.  American Journal of Preventive Medicine 42(2): 109-119, 2012.

    7.      Pence BD, Martin SA, Woods JA.  Effects of exercise on immunosenescence in aged populations.  American Journal of Lifestyle Medicine 5(3): 238-246, 2011.

    6.      Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, Kim JS, Heo S, Alves H, White SM, Wojcicki TR, Mailey E, Vieira VJ, Martin SA, Pence BD, Woods JA, McAuley E, Kramer AF.  Exercise training increases size of the hippocampus and improves memory.  Proceedings of the National Academy of Sciences USA  108(7): 3017-3022, 2011.

    5.      Coen PM, Flynn MG, Markofski MM, Pence BD, Hannemann RE.  Adding exercise to rosuvastatin treatment: influence on C-reactive protein, monocyte toll-like receptor 4 expression and inflammatory monocyte (CD14+CD16+) population. Metabolism 59: 1775-1783, 2010.

    4.      Erickson KI, Prakash RS, Voss MW, Chaddock L, Heo S, McLaren M, Pence BD, Martin SA, Vieira VJ, Woods JA, Kramer AF.  BDNF is associated with age-related decline in hippocampal volume.  Journal of Neuroscience 30(15): 5368-5375, 2010.

    3.      Martin SA, Pence BD, Woods JA.  Exercise and respiratory tract viral infection. Exercise and Sports Sciences Reviews 37(4): 157-164, 2009.

    2.      Coen PM, Flynn MG, Markofski MM, Pence BD, Hannemann RE.  Adding exercise training to rosuvastatin treatment: influence on serum lipids and biomarkers of muscle and liver damage. Metabolism 58(7): 1030-1038, 2009.

    1.      Timmerman KL, Flynn MG, Coen PM, Markofski MM, Pence BD. Exercise training-induced lowering of inflammatory (CD14+CD16+) monocytes: a role in the anti-inflammatory influence of exercise
Presentations
  • 33.    Recombinant SARS-CoV-2 spike protein mediates glycolytic and inflammatory activation in human monocytes. Gerontological Society of America Annual Meeting, 2020. (Virtual Poster)

    32.    Immunometabolic activation of monocytes by SARS-CoV-2 spike protein suggests potential therapeutic role of geroprotector drugs. American Aging Association Meeting, 2020. (Virtual Poster)

    31.    Growth differentiation factor 15 is correlated to markers of immunosenescence in monocytes. Gerontological Society of American Annual Meeting, 2019. Austin, TX. (Poster)

    30.    GDF-15 is correlated with monocyte immunosenescence indicators. American Aging Association Annual Meeting, 2019. Burlingame, CA. (Poster)

    29.    Growth/Differentiation Factor-15 is correlated to markers of immunosenescence in monocytes. Oklahoma Geroscience Symposium, 2019. Oklahoma City, OK. (Poster)

    28.    Aging alters respiratory but not glycolytic capacity in human monocytes. Gerontological Society of American Annual Meeting, 2018. Boston, MA. (Poster)

    27.    Aging alters respiratory but not glycolytic capacity in human monocytes. Nathan Shock Center Symposium, University of Alabama-Birmingham, 2018. Birmingham, AL. (Poster)

    26.    Aging impairs monocyte mitochondrial respiration and increases proportion of non-classical phenotype. Keystone Symposium on Aging, Inflammation and Immunity, 2018. Austin, TX. (Poster)

    25.    Voluntary wheel running and response to vaccinia virus infection and inoculation in mice.  ACSM Annual Meeting, 2017. Denver, CO. (Slide)

    24.    Voluntary wheel running in mice is safe during vaccinia virus infection and does not impair vaccine responses. Experimental Biology 2017. Chicago, IL. (Poster).

    23.    Effects of dietary fiber and exercise on cognition, muscle function, and SCFA in young mice.  ACSM Annual Meeting, 2016.  Boston, MA.  (Poster).

    22.    EGCG decreases mortality in a dose-dependent fashion but does not improve cognition in mice.  Experimental Biology 2016.  Emerging Leaders in Nutrition Science Poster Competition, ASN.  San Diego, CA.  (Poster).

    21.    EGCG decreases mortality in a dose-dependent fashion but does not improve cognition in mice.  Experimental Biology 2016.  San Diego, CA.  (Slide).

    20.    Dietary fiber and exercise: Effects on muscle function, cognition, and short-chain fatty acids in mice.  Experimental Biology 2016.  San Diego, CA.  (Poster)

    19.    EGCG decreases mortality in a dose-dependent fashion but does not improve cognition in mice.  Cognition, Lifespan Engagement, Aging, and Resilience (CLEAR) Initiative, Beckman Institute, University of Illinois at Urbana-Champaign.  Urbana, IL.  (Poster).

    18.    Diet containing EGCG and beta-alanine decreases mortality, but has no effect on cognitive function and variably affects muscle function in aged mice.  ACSM Annual Meeting, 2015.  San Diego, CA.  (Poster).

    17.    Metabolic activation: A potential mechanism for exercise-induced phenotypic switch in macrophages.  ACSM Annual Meeting, 2015.  San Diego, CA.  (Slide)

    16.    A diet containing EGCG and beta-alanine decreases mortality and improves balance in aged mice, but does not affect cognitive function.  Experimental Biology 2015.  Boston, MA.  (Slide)

    15.    A diet containing EGCG and beta-alanine decreases mortality and improves balance in aged mice, but does not affect cognitive function.  Experimental Biology 2015.  Emerging Leaders in Nutrition Science Poster Competition, ASN.  Boston, MA.  (Poster).

    14.    A diet containing EGCG and beta-alanine decreases mortality and improves balance in aged mice, but does not affect cognitive function.  Experimental Biology 2015.  The Postdoctoral Research Award Competition, ASN.  Boston, MA.  (Slide).

    13.    Voluntary wheel running and a diet containing EGCG and Beta-alanine: Effects on cognition and muscle function.  Illinois Brain Behavior and Immunity Meeting, 2015.  Chicago, IL.  (Slide).

    12.    Impact of exercise and/or beta-alanine and EGCG on muscle function and inflammation in aged mice.  ACSM Annual Meeting, 2014.  Orlando, FL.  (Poster).

    11.    Impact of exercise and/or beta-alanine and epigallocatechin gallate on muscle function and oxidative stress in aged mice.  Experimental Biology 2014. San Diego, CA.  (Poster).

    10.    Sex differences in healing rate of cutaneous wounds in mice: No impact of exercise.  ACSM Annual Meeting, 2013.  Indianapolis, IN.  (Poster).

    9.      Treadmill exercise ameliorates delayed healing in obese versus lean mice.  MWACSM Annual Meeting, 2011.  Indianapolis, IN.  (Slide).

    8.      Exercise influence on wound healing and tissue inflammation in obese high-fat diet-fed mice.  10th ISEI Conference, 2011.  Oxford, UK.  (Slide).

    7.      Effects of exercise on wound healing and wound tissue inflammation in obese mice.  18th PNIRS Conference, 2011.  Chicago, IL.  (Slide).

    6.      Exercise speeds wound healing rate in diet-induced obese mice.  ACSM Annual Meeting, 2011. Denver, CO.  (Thematic Poster).

    5.      No effect of dietary yeast beta-glucan on antibody or cell-mediated response to influenza virus vaccine. 17th PNIRS Conference, 2010.  Dublin, Ireland.  (Poster).

    4.      Associations between gene expression of Toll-like receptor 4 and markers of inflammation in adipose tissue: the role of exercise. 9th ISEI Conference, 2009. Tübingen, Germany.  (Poster).

    3.      Aerobic exercise does not improve delayed-type hypersensitivity to tetanus or candida in older adults. ACSM Annual Meeting, 2009. Seattle, WA.  (Poster).

    2.      Exercise training-induced improvements in antibody responses to influenza vaccination in older adults are related to changes in cardiovascular fitness.  APS Integrative Biology of Exercise V, 2008. Hilton Head, SC. (Poster).

    1.      Effect of cardiovascular exercise on CRP levels in previously sedentary older men and women. Experimental Biology, 2008. San Diego, CA.